Female genomic response to mate information
Female genomic response to mate information
复制标题
DOI：
10.1073/pnas.1010442107
复制
发表时间：
2010-12-07
影响因子：
11.1
通讯作者：
Fernald, Russell D.
中科院分区：
文献类型：
--
作者：
Desjardins, Julie K.;Klausner, Jill Q.;Fernald, Russell D.
对于未来的伴侣，女性应该比男性更挑剔，因为不适当的交配决定会带来高昂的成本。理论和实证研究都确定了可能影响女性择偶的因素。然而，男性和男性之间的社交互动也会影响交配决定，因为关于潜在伴侣的信息会引发女性生殖生理的变化。我们询问了关于首选男性的社交信息如何影响女性的神经活动，使用即刻早期基因(IEG)的表达作为大脑活动的代理。一条怀孕的雌性慈尾鱼(Astatotilapia Burtoni)在两个社会地位相当的雄性之间进行选择，然后看到这两个雄性之间的打斗，她喜欢的雄性要么赢，要么输。我们测量了几个脑核中IEG的表达水平，包括脊椎动物社会行为网络(SBN)中的那些，这是已知在社会行为中重要的脑核的集合。当雌性看到她喜欢的雄性赢得一场战斗时，与生殖相关的SBN核被激活，但当她看到她喜欢的雄性输掉一场战斗时，与焦虑相关的核--外侧隔核--被激活。因此，单独的社交信息，独立于实际的社交互动，激活特定的大脑区域，这些区域根据女性所看到的明显不同。在女性大脑中，当她选择胜利者时，生殖中心被激活，而当她选择失败者时，类似焦虑的反应中心被激活。这些实验使用连续呈现配偶信息的范式来评估配偶选择信息在大脑中的作用，这表明可以通过IEG表达来理解社交信息对动物的影响。
Females should be choosier than males about prospective mates because of the high costs of inappropriate mating decisions. Both theoretical and empirical studies have identified factors likely to influence female mate choices. However, male-male social interactions also can affect mating decisions, because information about a potential mate can trigger changes in female reproductive physiology. We asked how social information about a preferred male influenced neural activity in females, using immediate early gene (IEG) expression as a proxy for brain activity. A gravid female cichlid fish (Astatotilapia burtoni) chose between two socially equivalent males and then saw fights between these two males in which her preferred male either won or lost. We measured IEG expression levels in several brain nuclei including those in the vertebrate social behavior network (SBN), a collection of brain nuclei known to be important in social behavior. When the female saw her preferred male win a fight, SBN nuclei associated with reproduction were activated, but when she saw her preferred male lose a fight, the lateral septum, a nucleus associated with anxiety, was activated instead. Thus social information alone, independent of actual social interactions, activates specific brain regions that differ significantly depending on what the female sees. In female brains, reproductive centers are activated when she chooses a winner, and anxiety-like response centers are activated when she chooses a loser. These experiments assessing the role of mate-choice information on the brain using a paradigm of successive presentations of mate information suggest ways to understand the consequences of social information on animals using IEG expression.