ABO blood group and cancer
ABO blood group and cancer
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DOI：
10.1016/j.ejca.2010.08.009
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发表时间：
2010-12-01
影响因子：
8.4
通讯作者：
Lowenfels, Albert B.
中科院分区：
文献类型：
--
作者：
Iodice, Simona;Maisonneuve, Patrick;Lowenfels, Albert B.
背景：ABO血型与多种恶性肿瘤有关，包括胰腺癌。我们的目的是研究这种关联使用的数据从医院为基础的肿瘤registration.Methods：从肿瘤登记处，我们检索数据，从15,359癌症患者在2000-2003年在欧洲肿瘤研究所（米兰，意大利），ABO血型的定义。我们进行了病例对照分析，比较了每种特定癌症患者的ABO血型分布与其他癌症患者的ABO血型分布。我们还回顾了文献，并进行了一项关于ABO血型与胰腺癌之间关系的荟萃分析。结果：我们观察到，与其他形式的癌症患者相比，外分泌型胰腺癌患者中0型血的频率明显较低（29%对44%; P < 0.001;比值比（OR），0.53; 95%置信区间（CI），0.33-0.83）。这一关联已被7项既往研究的荟萃分析证实（汇总相对风险，0.79; 95%CI，0.70-0.90）。没有发现关联内分泌胰腺癌或癌症起源于其他organs.Conclusions：我们的数据表明，ABO血型和癌症之间的关联仅限于外分泌胰腺恶性肿瘤。(C)2010爱思唯尔有限公司保留所有权利。
Background: ABO blood type has been associated with various malignancies, including pancreatic cancer. Our aim was to study this association using data from a hospital-based tumour registry.Methods: From the tumour registry, we retrieved data from 15,359 cancer patients treated during 2000-2003 at the European Institute of Oncology (Milan, Italy), with defined ABO blood type. We performed a case-control analysis, comparing the distribution of ABO blood types of patients with each specific form of cancer against that of patients with other forms of cancer. We also reviewed the literature and performed a meta-analysis on the association between ABO blood group and pancreatic cancer.Results: We observed a significantly lower frequency of blood type 0 in patients with exocrine pancreatic cancer compared to patients with other forms of cancer (29% versus 44%; P < 0.001; odds ratio (OR), 0.53; 95% confidence intervals (CI), 0.33-0.83). This association was confirmed by the meta-analysis of seven prior studies (summary relative risk, 0.79; 95% CI, 0.70-0.90). No association was found for endocrine pancreatic cancer or for cancer originating in other organs.Conclusions: Our data suggest that the association between ABO blood group and cancer is limited to exocrine pancreas malignancy. (C) 2010 Elsevier Ltd. All rights reserved.