Synthesis and Application of Trehalose Materials.
Synthesis and Application of Trehalose Materials.
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DOI：
10.1021/jacsau.2c00309
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发表时间：
2022-07-25
期刊：
影响因子：
8
通讯作者：
Maynard, Heather D
中科院分区：
文献类型：
--
作者：
Vinciguerra, Daniele;Gelb, Madeline B;Maynard, Heather D
海藻糖是一种天然存在的非还原性二糖，由于其稳定和冷冻保护特性而广泛应用于生物制药、食品和化妆品行业。多年来，科学家们开发出了合成具有海藻糖单元的线性聚合物的方法，这些聚合物可以在聚合物主链中，也可以作为侧基。这些大分子具有独特的性质和特性，通常优于海藻糖本身。此外，许多报告都集中在基于海藻糖的材料的合成和配方上，例如纳米颗粒、水凝胶和热固性网络。在许多应用中，这些聚合物和材料已被用作蛋白质稳定剂、基因递送系统以及防止淀粉样蛋白聚集体的形成。在这篇文章中，讨论了基于海藻糖的线性聚合物、水凝胶和纳米材料的合成和应用的最新进展，重点关注在生物医学领域的应用。
Trehalose is a naturally occurring, nonreducing disaccharide that is widely used in the biopharmaceutical, food, and cosmetic industries due to its stabilizing and cryoprotective properties. Over the years, scientists have developed methodologies to synthesize linear polymers with trehalose units either in the polymer backbone or as pendant groups. These macromolecules provide unique properties and characteristics, which often outperform trehalose itself. Additionally, numerous reports have focused on the synthesis and formulation of materials based on trehalose, such as nanoparticles, hydrogels, and thermoset networks. Among many applications, these polymers and materials have been used as protein stabilizers, as gene delivery systems, and to prevent amyloid aggregate formation. In this Perspective, recent developments in the synthesis and application of trehalose-based linear polymers, hydrogels, and nanomaterials are discussed, with a focus on utilization in the biomedical field.
海藻糖多阳离子终端官能化对质粒DNA摄取和转染的影响。
影响因子：
6.2
作者：
Anderson, Kevin;Sizovs, Antons;Cortez, Mallory;Waldron, Chris;Haddleton, D. M.;Reineke, Theresa M.
通讯作者：
Reineke, Theresa M.