Design and subject characteristics in the federally-funded citalopram trial in children with pervasive developmental disorders.
Design and subject characteristics in the federally-funded citalopram trial in children with pervasive developmental disorders.
复制标题
联邦政府资助的针对患有广泛性发育障碍的儿童的西酞普兰试验的设计和受试者特征。
DOI：
10.1007/s10803-011-1251-8
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发表时间：
2012
影响因子：
3.9
通讯作者：
Wagner,An
中科院分区：
文献类型：
--
作者：
Scahill,Lawrence;McCracken,JamesT;Bearss,Karen;Robinson,Fay;Hollander,Eric;King,Bryan;Bregman,Joel;Sikich,Lin;Dukes,Kimberly;Sullivan,Lisa;Anagnostou,Evdokia;Donnelly,Craig;Kim,Young-Shin;Ritz,Louise;Hirtz,Deborah;Wagner,An
研究推进自闭症研究和治疗网络对普适性发育障碍(PDDS)儿童进行了一项西酞普兰的随机试验。我们介绍了西酞普兰试验的理论基础、设计和样本特征。受试者(男孩128人，女孩21人)平均年龄9.3(±3.12)岁；132人(88.6%)被诊断为自闭症(4.7%为阿斯伯格障碍；6.7%为PDD--未指明)。不到一半的受试者智力残疾；117人(78.5%)被评为中等或在临床总体印象中被评为严重程度。研究措施类似于以前的儿科精神药理学试验研究单位。与RUPP试验的参与者相比，这项试验的受试者年龄稍大，更有可能抱怨重复的行为。
The Studies to Advance Autism Research and Treatment Network conducted a randomized trial with citalopram in children with Pervasive developmental disorders (PDDs). We present the rationale, design and sample characteristics of the citalopram trial. Subjects (128 boys, 21 girls) had a mean age of 9.3 (±3.12) years; 132 (88.6%) were diagnosed with autistic disorder (4.7% with Asperger’s Disorder; 6.7% with PDD-not otherwise specified). Less than half of the subjects were intellectually disabled; 117 (78.5%) were rated Moderate or Marked on the Clinical Global Impression for Severity. Study measures were similar to previous Research Units on Pediatric Psychopharmacology trials. Subjects in this trial were slightly older and more likely to have complaints of repetitive behavior than participants in RUPP trials.