Invariance (?) of mutational parameters for relative fitness over 400 generations of mutation accumulation in Caenorhabditis elegans.
Invariance (?) of mutational parameters for relative fitness over 400 generations of mutation accumulation in Caenorhabditis elegans.
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DOI：
10.1534/g3.112.003947
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发表时间：
2012-12
期刊：
影响因子：
--
通讯作者：
Baer CF
中科院分区：
文献类型：
--
作者：
Matsuba C;Lewis S;Ostrow DG;Salomon MP;Sylvestre L;Tabman B;Ungvari-Martin J;Baer CF
越来越多的证据表明，生理状况不佳的个体可能比生理状况良好的个体更快地积累突变损伤。如果不良状况是由预先存在的有害突变造成的，那么结果就是“适应度依赖性突变率”，这具有有趣的理论含义。在这里，我们报告了一项研究，其中10个突变积累（MA）线的线虫秀丽隐杆线虫，以前积累了250代的突变，在宽松的选择下扩展到集的“二阶”MA线，并允许积累突变额外的150代。根据前250代MA的适应性相对变化，选择了10个品系，5个高适应性品系和5个低适应性品系。平均而言，高适应度和低适应度的突变特性（平均相对适应度、突变方差和基因组突变率和平均突变效应的Bateman-Mukai估计值的每代变化）没有显著差异，并且在所有品系上平均，在200代MA后，点估计值非常接近一阶MA实验的点估计值。然而，一些不显著的趋势表明，低健身线可能实际上更容易遭受突变的损害比高健身线。
Evidence is accumulating that individuals in poor physiologic condition may accumulate mutational damage faster than individuals in good condition. If poor condition results from pre-existing deleterious mutations, the result is “fitness-dependent mutation rate,” which has interesting theoretical implications. Here we report a study in which 10 mutation accumulation (MA) lines of the nematode Caenorhabditis elegans that had previously accumulated mutations for 250 generations under relaxed selection were expanded into sets of “second-order” MA lines and allowed to accumulate mutations for an additional 150 generations. The 10 lines were chosen on the basis of the relative change in fitness over the first 250 generations of MA, five high-fitness lines and five low-fitness lines. On average, the mutational properties (per-generation change in mean relative fitness, mutational variance, and Bateman-Mukai estimates of genomic mutation rate and average mutational effect) of the high-fitness and low-fitness did not differ significantly, and averaged over all lines, the point estimates were extremely close to those of the first-order MA experiment after 200 generations of MA. However, several nonsignificant trends indicate that low-fitness lines may in fact be more likely to suffer mutational damage than high-fitness lines.
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影响因子：
11.4
作者：
Lynch, Michael
通讯作者：
Lynch, Michael
DOI：
10.1098/rspb.2000.0976
发表时间：
2000-01-22
影响因子：
4.7
作者：
Goho, S;Bell, G
通讯作者：
Bell, G
DOI：
10.1007/bf02984796
发表时间：
1959-01-01
期刊：
Journal of Genetics Calcutta
影响因子：
--
作者：
Bateman, K. G.
通讯作者：
Bateman, K. G.
DOI：
10.1073/pnas.021390798
发表时间：
2001-01-30
影响因子：
11.1
作者：
Szafraniec, K;Borts, RH;Korona, R
通讯作者：
Korona, R
影响因子：
2.1
作者：
Agrawal, AF
通讯作者：
Agrawal, AF