Incidence of age-related cataract over a 15-year interval
Incidence of age-related cataract over a 15-year interval
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DOI：
10.1016/j.ophtha.2007.11.024
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发表时间：
2008-03-01
期刊：
影响因子：
13.7
通讯作者：
Gangnon, Ronald E.
中科院分区：
文献类型：
--
作者：
Klein, Barbara E. K.;Klein, Ronald;Gangnon, Ronald E.
目的：描述核性白内障、皮质性白内障和后囊膜下白内障（PSC）的长期发病率，并评估年龄和队列对这些发病率的影响。设计：基于人群的研究。参与者：海狸坝眼科研究队列的成员。方法：在研究办公室对受试者进行检查（裂隙灯、检查遮挡角度、瞳孔放大、镜头照片、测量血压和研究访谈）。主要结果测量：镜头照片是用特殊改装的相机拍摄的，在所有研究检查过程中一直保持。照片是根据标准方案进行评分的，并在所有的考试中继续进行。结果：核性白内障的累计发病率为29.7%(95%可信区间[CI]， 28.0 ~ 31.4)；皮质性白内障，22.9% (95% CI, 21.3-24.5)；Psc, 8.4% (95% ci, 7.4-9.4)；白内障手术，17.7% （95% CI, 16.4-19.0）。累积发病率随着年龄的增长而增加，考虑到比赛项目后，女性的发病率更高。年龄与白内障发病率的关系对于核性白内障为二次关系，对于皮质性白内障为立方关系，对于PSC为线性关系。在接受检查时年龄相仿的人中，出生较晚的人患任何类型的普遍白内障的可能性较低；在核性白内障和白内障手术中效果显著，在控制相关混杂因素后效果持续。白内障发病率有明显的队列效应。结论：各类型白内障的年龄调整发生率均随年龄的增长而增加，但年龄对三种类型白内障的影响均不是线性的。相对于较早出生的人，较晚出生的人相对受到保护。需要进一步的随访来验证我们报告的趋势，并确定队列对10年发病率的影响是否显著。
Objective: To describe the long-term incidence of nuclear cataract, cortical cataract, and posterior subcapsular cataract (PSC) and to evaluate age and cohort effects on these rates.Design: Population-based study.Participants: Members of the Beaver Dam Eye Study cohort.Methods: Subjects were seen in study offices for examinations (slit lamp, checking for occluclable angles, dilation of pupils, lens photographs, measurement of blood pressures, and study interview).Main Outcome Measures: Lens photographs were taken with specially modified cameras that have been maintained over the course of all study examinations. Photographs were graded according to standard protocols that have been continued throughout all the examinations.Results: Cumulative incidence of nuclear cataract was 29.7% (95% confidence interval [CI], 28.0-31.4); cortical cataract, 22.9% (95% CI, 21.3-24.5); PSC, 8.4% (95% CI, 7.4-9.4); and cataract surgery, 17.7% (95% CI, 16.4-19.0). The cumulative incidence increased with age and was greater for women after accounting for competing events. The relationship between age and incidence of cataracts was quadratic for nuclear cataract, cubic for cortical cataract, and linear for PSC. For persons with similar ages at time of examination, those in more recent birth cohorts were less likely to have any type of prevalent cataract; the effect was significant for nuclear cataract and for cataract surgery, and the effect persisted after controlling for relevant confounders. There were apparent cohort effects on cataract incidence.Conclusions: Age-adjusted incidence of all cataract types increased with increasing age, although the age effect was not linear for all 3 types. More recent birth cohorts are relatively protected relative to persons born earlier. Further follow-up is needed to verify the trends we report here and to determine whether cohort effects on 10-year incidence are significant.