REGULATORY MECHANISMS THAT COORDINATE SKELETAL-MUSCLE DIFFERENTIATION AND CELL-CYCLE WITHDRAWAL
REGULATORY MECHANISMS THAT COORDINATE SKELETAL-MUSCLE DIFFERENTIATION AND CELL-CYCLE WITHDRAWAL
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DOI：
10.1016/0955-0674(94)90046-9
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发表时间：
1994-12-01
影响因子：
7.5
通讯作者：
NOVITCH, B
中科院分区：
文献类型：
--
作者：
LASSAR, AB;SKAPEK, SX;NOVITCH, B
骨骼肌分化需要肌肉特异性基因表达与细胞周期最终退出的耦合。最近提出了几个模型，试图解释肌源性转录因子的调控表达和功能如何确保骨骼肌细胞的增殖和分化是相互排斥的过程。
Skeletal muscle differentiation entails the coupling of muscle-specific gene expression to terminal withdrawal from the cell cycle. Several models have recently been proposed which attempt to explain how regulated expression and function of myogenic transcription factors ensures that proliferation and differentiation of skeletal muscle cells are mutually exclusive processes.