Association of anemia and erythropoiesis stimulating agents with inflammatory biomarkers in chronic kidney disease
Association of anemia and erythropoiesis stimulating agents with inflammatory biomarkers in chronic kidney disease
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DOI：
10.1038/ki.2008.245
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发表时间：
2008-09-01
影响因子：
19.6
通讯作者：
Singh, Ajay K.
中科院分区：
文献类型：
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作者：
Keithi-Reddy, Sai Ram;Addabbo, Francesco;Singh, Ajay K.
炎症细胞因子是心血管死亡率的重要预测因子，尤其是慢性肾病患者。在这里，我们探讨了贫血和促红细胞生成素治疗与慢性肾病患者炎症细胞因子水平的关系。 100 名 18 岁以上患有慢性肾病的非透析患者被平均分为贫血组和非贫血组。在 50 名贫血患者中，23 名正在接受红细胞生成刺激剂治疗。与非贫血患者相比，贫血患者的肿瘤坏死因子 (TNF)-α 水平显着升高，血清白蛋白显着降低，且白细胞介素 (IL)-6 和 IL-8 呈升高趋势。通过多元逻辑回归进一步分析发现，与非贫血患者相比，接受红细胞生成刺激剂治疗的贫血患者 IL-6、IL-8 和 TNF-α 达到上两个四分位数的几率显着更高。我们的研究发现，在接受依泊汀治疗的患者中，慢性肾病贫血与 TNF-α、IL-6 和 IL-8 的上调以及这些促炎细胞因子水平的升高有关。
Inflammatory cytokines are important predictors of cardiovascular mortality especially in patients with chronic kidney disease. Here we explored the relationship of anemia and epoetin treatment to inflammatory cytokine levels in patients with chronic kidney disease. One hundred non-dialysis patients with chronic kidney disease over 18 years of age were evenly split into anemic and non-anemic cohorts. Of the 50 anemic patients, 23 were receiving erythropoiesis stimulating agents treatments. Levels of tumor necrosis factor (TNF)-alpha were found to be significantly higher and serum albumin was significantly lower with trends towards higher interleukin (IL)-6 and IL-8 in anemic compared to non-anemic patients. Further analysis by multiple logistic regression found that anemic patients treated with erythropoiesis stimulating agents had significantly higher odds for the upper two quartiles for IL-6, IL-8 and TNF-alpha compared to non-anemic patients. Our study found that the anemia of chronic kidney disease was associated with up regulation of TNF-alpha, and possibly IL-6 and IL-8 along with increased levels of these proinflammatory cytokines in patients treated with epoetin.