Pattern Separation Deficits May Contribute to Age-Associated Recognition Impairments
Pattern Separation Deficits May Contribute to Age-Associated Recognition Impairments
复制标题
DOI：
10.1037/a0020893
复制
发表时间：
2010-10-01
影响因子：
1.9
通讯作者：
Barnes, Carol A.
中科院分区：
文献类型：
--
作者：
Burke, Sara N.;Wallace, Jenelle L.;Barnes, Carol A.
正常衰老与刺激识别的损伤有关在当前的研究中，用标准自发物体识别（SOR）任务或该任务的两个变体在成年和老年大鼠中测试物体识别。在标准SOR任务中，成年大鼠显示出对新物体的探索偏好超过延迟长达24小时，而老年大鼠仅在2分钟延迟时表现出显著的新奇辨别。这种年龄差异似乎是因为老年大鼠表现得好像新奇物体是熟悉的。为了直接检验这一假设，大鼠参与SOR任务的一个变体，该变体允许比较对象熟悉和测试阶段之间的探索时间。并且该实验证实了老年大鼠错误地“识别”新物体。在该实验中，最后的对照检查了老年大鼠是否表现出探索物体的动机降低。当环境背景在熟悉和测试之间改变时，年轻和年老的大鼠没有表现出探索偏好，因为两个年龄组花费更多的时间探索熟悉的物体。这些发现一起支持了这样的观点，即物体识别中与年龄相关的损伤是由于年老的动物表现得好像新物体是熟悉的，这让人联想到有嗅周皮层损伤的年轻大鼠的行为障碍。因此，目前的实验表明，嗅周皮层的改变可能是老年动物辨别能力下降的原因。来自以前遇到的新刺激
Normal aging is associated with impairments in stimulus recognition In the current investigation, object recognition was tested in adult and aged rats with the standard spontaneous object recognition (SOR) task or two variants of this task On the standard SOR task, adult rats showed an exploratory preference for the novel object over delays up to 24 h, whereas the aged rats only showed significant novelty discrimination at the 2-min delay This age difference appeared to be because of the old rats behaving as if the novel object was familiar To test this hypothesis directly, rats participated in a variant of the SOR task that allowed the exploration times between the object familiarization and the test phases to be compared. and this experiment confirmed that aged rats falsely "recognize" the novel object A final control examined whether or not aged rats exhibited reduced motivation to explore objects In this experiment. when the environmental context changed between familiarization and test, young and old rats failed to show an exploratory preference because both age groups spent more time exploring the familiar object Together these findings support the view that age-related impairments in object recognition arise from old animals behaving as if novel objects are familiar, which is reminiscent of behavioral impairments in young rats with perirhnal cortical lesions The current experiments thus suggest that alterations in the perirhinal cortex may be responsible for reducing aged animals' ability to distinguish new stimuli from ones that have been encountered previously