Endoglin (CD105) is a more appropriate marker than CD31 for detecting microvessels in carotid artery plaques.
Endoglin (CD105) is a more appropriate marker than CD31 for detecting microvessels in carotid artery plaques.
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DOI：
10.4103/2152-7806.119081
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发表时间：
2013-01-01
影响因子：
--
通讯作者：
Miyamoto, Susumu
中科院分区：
文献类型：
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作者：
Fukumitsu, Ryu;Takagi, Yasushi;Miyamoto, Susumu
背景：微血管增生是颈动脉狭窄患者斑块易损性的主要危险因素。有几种血管内皮标记物，如CD31和CD105，但目前还不清楚哪种标记物对微血管最敏感。本研究旨在探讨颈动脉斑块微血管中CD 31和CD 105表达与临床表现的相关性。患者接受颈动脉内膜切除术，并对样本进行CD 31和CD 105染色。结果：CD31和CD105的平均微血管数分别为5.8 ± 5.4和9.2 ± 9.3（P = 0.04）。结论：在颈动脉狭窄患者中，CD105比CD31更适合检测颈动脉斑块内的微血管。在糖尿病患者中，CD105在微血管中的表达显著高于CD31。
BACKGROUND: Microvascular proliferation is a major risk factor for plaque vulnerability in patients with carotid stenosis. There are several vascular endothelial markers such as CD31 and CD105, but it is unclear which marker is most sensitive for microvessels. This study sought to examine the correlations between CD31 and CD105 expression in microvessels on carotid plaques and clinical manifestations.METHODS: We studied 13 lesions in 12 patients. The patients underwent carotid endarterectomy and samples were stained for CD31 and CD105. The numbers of microvessels positive for these markers within a field of view were counted.RESULTS: The average numbers of microvessels were 5.8 ± 5.4 for CD31 and 9.2 ± 9.3 for CD105 (P = 0.04). More microvessels were positive for CD105 than there were for CD31 in patients with diabetes mellitus (P = 0.04).CONCLUSION: In patients with carotid artery stenosis, CD105 is more appropriate than CD31 for detecting microvessels in carotid plaques. In patients with diabetes mellitus, CD105 is significantly more highly expressed in microvessels than CD31.