Female infants are more susceptible to the effects of maternal antenatal depression; findings from the Pelotas (Brazil) Birth Cohort Study.
Female infants are more susceptible to the effects of maternal antenatal depression; findings from the Pelotas (Brazil) Birth Cohort Study.
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女婴更容易受到母亲产前抑郁症的影响；
DOI：
10.1016/j.jad.2020.02.025
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发表时间：
2020
影响因子：
6.6
通讯作者：
Netsi E
中科院分区：
文献类型：
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作者：
Netsi E
BackgroundWe利用数据从2015年Pelanmar出生队列，在巴西南部的一个大型前瞻性队列，研究中度和重度产前抑郁症与儿童出生结局的关联，并探讨与社会人口特征的相互作用。MethodsData可用于n = 3046参与者和他们的婴儿。我们使用爱丁堡产后抑郁量表（EPDS，≥13为中度抑郁，≥17为重度抑郁）测量产前抑郁。结果指标包括胎龄、出生体重、身长和头围，采用Intergrowth-21标准。我们控制了已知的混杂因素，包括产科risk.ResultsWe没有发现产妇抑郁状态的参与者至少有中度抑郁症的分娩结局的差异，虽然有一个风险增加的女性后代是小胎龄（SGA，OR 2.33[1.37，3.97]）。对于重度抑郁症（EPDS≥17），我们发现APGAR评分较低的风险增加（OR 1.63[1.02，2.60]）且为SGA（OR 1.77[1.06，2.97]，雌性后代的风险增加，特别是体重较低的百分位数（-10.71 [-16.83，-4.60]），为SGA（OR 3.74[1.89，7.44]）和在较低的第10个百分位数的长度（OR 2.19[1.25，3.84]）.Limitationsinclude使用的产妇报告问卷，以确定抑郁symptoms.ConclusionsIn这个最近的大型纵向队列在巴西，我们没有发现独立的影响抑郁症的不良出生结果或相互作用与社会人口特征。我们发现一个增加的风险是SGA的女性后代的妇女与中度和重度抑郁症，与其他研究表明女性可能更容易受到产前disturbs.FundingThis工作是由惠康信托基金，英国（095582），巴西国家研究理事会（CNPQ）和协调高等教育人员（CAPES）的改进。EN得到了英国经济和社会研究理事会GCRF博士后研究金（ES/P009794/1）的支持。
BackgroundWe utilised data from the 2015 Pelotas Birth Cohort, a large prospective cohort in southern Brazil, to examine the association of moderate and severe antenatal depression with child birth outcomes and explore interactions with sociodemographic characteristics.MethodsData was available forn= 3046 participants and their infants. We measured antenatal depression using the Edinburgh Postnatal Depression Scale (EPDS, ≥13 for moderate and ≥17 for severe depression). Outcome measures included gestational age, birth weight, length and head circumference, using the Intergrowth-21st standards. We controlled for known confounders including obstetric risk.ResultsWe did not find differences in childbirth outcomes by maternal depression status for participants with at least moderate depression, although there was an increased risk for female offspring to be small for gestational age (SGA, OR 2.33[1.37,3.97]). For severe depression (EPDS≥17) we found an increased risk for lower APGAR scores (OR 1.63[1.02,2.60]) and being SGA (OR 1.77[1.06,2.97], with an increased risk for female offspring in particular to be in lower weight centiles (−10.71 [−16.83,−4.60]), to be SGA (OR 3.74[1.89, 7.44]) and in the lower 10th centile for length (OR 2.19[1.25,3.84]).Limitationsinclude the use of a maternal report questionnaire to ascertain depressive symptoms.ConclusionsIn this recent large longitudinal cohort in Brazil we did not find independent effects of depression on adverse birth outcomes or interactions with sociodemographic characteristics. We found an increased risk of being SGA for female offspring of women with moderate and severe depression, in line with other research suggesting females may be more susceptible to antenatal disturbances.FundingThis work was supported by the Wellcome Trust, United Kingdom (095582), the Brazilian National Research Council (CNPq) and the Coordination for the Improvement of Higher Education Personnel (CAPES). EN was supported by the UK Economic and Social Research Council GCRF Postdoctoral Fellowship (ES/P009794/1).