Autophagy‐independent mitochondrial quality control: Mechanisms and disease associations
Autophagy‐independent mitochondrial quality control: Mechanisms and disease associations
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DOI：
10.1002/mef2.25
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发表时间：
2022-09
期刊：
影响因子：
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通讯作者：
Feixiang Bao;Jiahui Xiao;Lingyan Zhou;Yanhua Xie;Yueqiao Li;Yi Wu;Xingguo Liu
中科院分区：
文献类型：
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作者：
Feixiang Bao;Jiahui Xiao;Lingyan Zhou;Yanhua Xie;Yueqiao Li;Yi Wu;Xingguo Liu
保持健康和功能的线粒体网络对细胞的生存和功能至关重要。由于生理适应和应激条件，蛋白质错误折叠和功能障碍在他们中特别普遍。为了线粒体的正常运作，已经发展了多种质量控制系统，以确保有足够的线粒体满足细胞的需求，使用这些途径可以消除受损的线粒体蛋白质或线粒体部分。有几种机制控制线粒体的质量，包括蛋白质、细胞器和细胞水平。作为对线粒体质量-有丝分裂吞噬的广泛研究，本文综述了与自噬无关的线粒体质量控制的过程和机制，包括线粒体蛋白和DNA降解、线粒体来源的小泡和线粒体来源的隔室、线粒体分泌、隧道纳米管、有丝分裂和线粒体溶酶体胞吐作用。了解这些新的质量控制途径可能会提供对线粒体稳态的洞察，并为这些系统失效的疾病开发有针对性的治疗方法。
Maintaining a healthy and functional mitochondrial network is crucial for cell survival and function. Protein misfolding and dysfunction are particularly prevalent in them due to physiological adaptations and stress conditions. For mitochondria to function properly, multiple quality control systems have evolved to ensure that there are enough mitochondria to meet cells’ needs, damaged mitochondrial proteins or mitochondrial parts can be eliminated using these pathways. Several mechanisms control mitochondrial quality, including protein, organelle, and cellular levels. As the extensive study of canonical mitochondrial quality‐mitophagy, this paper reviews the processes and mechanisms of mitochondrial quality control independent of autophagy, including mitochondrial protein and DNA degradation, mitochondria‐derived vesicles and mitochondria‐derived compartments, mitochondrial secretion, tunneling nanotubes, mitocytosis, and mitolysosome exocytosis. Understanding these novel quality control pathways may provide insights into mitochondrial homeostasis and for developing targeted treatments for diseases where these systems fail.