Autism symptoms in Attention-Deficit/Hyperactivity Disorder: A Familial trait which Correlates with Conduct, Oppositional Defiant, Language and Motor Disorders
Autism symptoms in Attention-Deficit/Hyperactivity Disorder: A Familial trait which Correlates with Conduct, Oppositional Defiant, Language and Motor Disorders
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DOI：
10.1007/s10803-008-0621-3
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发表时间：
2009-02-01
影响因子：
3.9
通讯作者：
Gill, Michael
中科院分区：
文献类型：
--
作者：
Mulligan, Aisling;Anney, Richard J. L.;Gill, Michael
据推测，自闭症症状存在于注意力缺陷多动障碍（ADHD）中，是ADHD的家族和指数亚型。比较了821名ADHD先证者、1050名兄弟姐妹和149名对照者的自闭症症状。使用DeFries-Fulker分析计算自闭症症状和ADHD的共同熟悉度。先证者的自闭症症状高于兄弟姐妹或对照组，男性兄弟姐妹的自闭症症状高于男性对照组。自闭症症状具有家族性，部分与男性ADHD的家族性相同。使用SCQ-score进行潜在分类分析得到5个类别；第1类（31%）几乎没有自闭症症状和低合并症；2-4班为中级；第5类（7%）有高度的自闭症症状和合并症。因此，ADHD的自闭症症状代表了一种与神经发育和对立/行为障碍增加相关的家族特征。
It is hypothesised that autism symptoms are present in Attention-Deficit/Hyperactivity Disorder (ADHD), are familial and index subtypes of ADHD. Autism symptoms were compared in 821 ADHD probands, 1050 siblings and 149 controls. Shared familiality of autism symptoms and ADHD was calculated using DeFries-Fulker analysis. Autism symptoms were higher in probands than siblings or controls, and higher in male siblings than male controls. Autism symptoms were familial, partly shared with familiality of ADHD in males. Latent class analysis using SCQ-score yielded five classes; Class 1(31%) had few autism symptoms and low comorbidity; Classes 2-4 were intermediate; Class 5(7%) had high autism symptoms and comorbidity. Thus autism symptoms in ADHD represent a familial trait associated with increased neurodevelopmental and oppositional/conduct disorders.