Long Non-coding RNAs in the Cytoplasm.
Long Non-coding RNAs in the Cytoplasm.
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细胞质中的长非编码RNA
DOI：
10.1016/j.gpb.2016.03.005
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发表时间：
2016-04
期刊：
影响因子：
--
通讯作者：
Shan G
中科院分区：
文献类型：
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作者：
Rashid F;Shah A;Shan G
真核生物基因组中转录出大量的长链非编码RNA（lncRNA），它们在细胞的各个方面都起着重要的调控作用。细胞质是许多lncRNA的驻留和作用位点。细胞质中的lncRNA在动物和人类细胞中发挥着不可或缺的作用，具有多种分子机制。本文就lncRNA在细胞质中的功能及其作用机制作一综述。我们强调了相对研究充分的细胞质lncRNA的例子，它们在调节mRNA稳定性、调节mRNA翻译、充当竞争性内源RNA、充当微小RNA的前体以及介导蛋白质修饰方面的作用。我们还阐述了细胞质lncRNA的研究前景。
An enormous amount of long non-coding RNAs (lncRNAs) transcribed from eukaryotic genome are important regulators in different aspects of cellular events. Cytoplasm is the residence and the site of action for many lncRNAs. The cytoplasmic lncRNAs play indispensable roles with multiple molecular mechanisms in animal and human cells. In this review, we mainly talk about functions and the underlying mechanisms of lncRNAs in the cytoplasm. We highlight relatively well-studied examples of cytoplasmic lncRNAs for their roles in modulating mRNA stability, regulating mRNA translation, serving as competing endogenous RNAs, functioning as precursors of microRNAs, and mediating protein modifications. We also elaborate the perspectives of cytoplasmic lncRNA studies.