Effects of CGRP on human osteoclast-like cell formation: a possible connection with the bone loss in neurological disorders?
Effects of CGRP on human osteoclast-like cell formation: a possible connection with the bone loss in neurological disorders?
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DOI：
10.1016/s0196-9781(00)00185-6
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发表时间：
2000-04-01
期刊：
影响因子：
3
通讯作者：
Bergmann, P
中科院分区：
文献类型：
--
作者：
Akopian, A;Demulder, A;Bergmann, P
在取自截瘫患者瘫痪区域的骨髓的长期培养物中，破骨细胞样细胞（OCL样）分化增加。在最近描述的骨中的神经肽中，降钙素基因相关肽（CGRP）已在动物研究中显示抑制体内骨吸收和体外OCL样分化：其缺乏因此可能是截瘫和一些其他神经系统疾病中神经损伤和OCL样产生增加之间的联系。因此，我们在这项研究中研究了CGRP对人OCL样形成的影响，发现它确实具有至少部分通过cAMP介导的抑制作用。(C)2000 Elsevier Science Inc. All rights reserved.
Osteoclast-like cell (OCL-like) differentiation is increased in long term cultures of bone marrow taken from paralyzed areas of paraplegic patients. Among the neuropeptides recently described in bone, calcitonin gene-related peptide (CGRP) has been shown in animal studies to inhibit bone resorption in vivo and OCL-like differentiation in vitro: its deficiency could thus be a link between the neural lesion and increased OCL-like production in paraplegia and some other neurologic disorders. We therefore investigated in this study the effects of CGRP on human OCL-like formation and found that it indeed has an inhibitory effect mediated at least in part via cAMP. (C) 2000 Elsevier Science Inc. All rights reserved.