A novel blood pressure modulator C1q/TNF-α-related protein 1 (CTRP1)
A novel blood pressure modulator C1q/TNF-α-related protein 1 (CTRP1)
复制标题
DOI：
10.5483/bmbrep.2018.51.12.268
复制
发表时间：
2018-01-01
期刊：
影响因子：
3.8
通讯作者：
Yang, Young
中科院分区：
文献类型：
--
作者：
Han, Sora;Yang, Young
C1q/肿瘤坏死因子-α相关蛋白1(CTRP1)最近被证明是一种血压调节剂，因为它可以诱导血管收缩。在主动脉中，CTRP1通过激活AKT/AS160信号通路促进血管紧张素II受体1(AT1R)向质膜的募集。这导致Ras同源基因家族(Rho)/Rho激酶(ROCK)信号通路的激活，导致血管收缩。因此，过度表达Ctrp1的小鼠具有高血压表型。与健康人相比，高血压患者的循环CTRP1水平也较高，这表明过量的CTRP1可能会影响高血压的发展。相反，CTRP1被认为是一种“天生的血压调节器”，因为CTRP1在脱水状态下会增加血压以防止低血压。缺乏Ctrp1的小鼠在脱水条件下无法维持正常血压，导致低血压，这表明CTRP1是维持血压稳态所必需的蛋白质。综上所述，CTRP1是一种新型的抗低血压药物，可在脱水引起的低血压过程中升高血压。
C1q/TNF-alpha-Related Protein 1 (CTRP1) has recently been shown to ad as a blood pressure regulator, as it induces vasoconstriction. In the aorta, CTRP1 facilitates recruitment of angiotensin II receptor 1 (AT1R) to plasma membrane, through activation of the AKT/AS160 signaling pathway. This leads to activation of the Ras homolog gene family (Rho)/Rho kinase (ROCK) signaling pathway, resulting in vasoconstriction. Accordingly, mice overexpressing Ctrp1 have hypertensive phenotype. Patients with hypertension also display higher circulating CTRP1 levels, compared to healthy individuals, indicating that excessive CTRP1 may affect development of hypertension. Conversely, CTRP1 is regarded as an 'innate blood pressure modulator' because CTRP1 increases blood pressure under dehydration to prevent hypotension. Mice lacking Ctrp1 fail to maintain normotension under dehydration conditions, resulting in hypotension, suggesting that CTRP1 is an essential protein for maintaining blood pressure homeostasis. In conclusion, CTRP1 is a novel, anti-hypotensive vasoconstrictor that increases blood pressure during dehydration-induced hypotension.