Findings from the Quebec Family Study on the Etiology of Obesity: Genetics and Environmental Highlights.
Findings from the Quebec Family Study on the Etiology of Obesity: Genetics and Environmental Highlights.
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DOI：
10.1007/s13679-013-0086-3
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发表时间：
2014
影响因子：
8.8
通讯作者：
Bouchard, Claude
中科院分区：
文献类型：
--
作者：
Chaput, Jean-Philippe;Perusse, Louis;Despres, Jean-Pierre;Tremblay, Angelo;Bouchard, Claude
魁北克家庭研究(QFS)是一项观察性研究，从1979年到2002年在加拿大魁北克市进行了三个周期的数据收集。队列是随机抽样和通过肥胖个体进行确定的混合体。在过去的35年里，这项研究对我们理解肥胖和相关疾病风险的决定因素做出了重大贡献。特别是，QFS队列被用来调查家族相似性和遗传效应对身体肥胖和与能量平衡相关的行为的贡献。总体肥胖度、脱脂体重、皮下脂肪分布、腹部和内脏脂肪、静息代谢率、体力活动水平等行为性状具有显著的家族聚集性和遗传遗传力。QFS的资源也被用来研究几个非传统(非热量)危险因素作为超重以及随着时间的推移体重和肥胖增加的预测因素的贡献，包括低钙和微量营养素摄入量，高去抑制进食行为特征，以及睡眠时间短。一个重要的发现与饮食中大量营养素的摄入量和运动强度对体重和肥胖症的相互作用有关。本文的在线版本(doi：10.1007/s13679-0130086-3)包含补充材料，授权用户可以使用。
The Quebec Family Study (QFS) was an observational study with three cycles of data collection between 1979 and 2002 in Quebec City, Canada. The cohort is a mixture of random sampling and ascertainment through obese individuals. The study has significantly contributed to our understanding of the determinants of obesity and associated disease risk over the past 35 years. In particular, the QFS cohort was used to investigate the contribution of familial resemblance and genetic effects on body fatness and behaviors related to energy balance. Significant familial aggregation and genetic heritability were reported for total adiposity, fat-free mass, subcutaneous fat distribution, abdominal and visceral fat, resting metabolic rate, physical activity level and other behavioral traits. The resources of QFS were also used to study the contribution of several nontraditional (non-caloric) risk factors as predictors of excess body weight and gains in weight and adiposity over time, including low calcium and micronutrient intake, high disinhibition eating behavior trait, and short sleep duration. An important finding relates to the interactions between dietary macronutrient intake and exercise intensity on body mass and adiposity. The online version of this article (doi:10.1007/s13679-013-0086-3) contains supplementary material, which is available to authorized users.