Association Between Arterial Hyperoxia Following Resuscitation From Cardiac Arrest and In-Hospital Mortality
Association Between Arterial Hyperoxia Following Resuscitation From Cardiac Arrest and In-Hospital Mortality
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DOI：
10.1001/jama.2010.707
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发表时间：
2010-06-02
影响因子：
120.7
通讯作者：
Trzeciak, Stephen
中科院分区：
文献类型：
--
作者：
Kilgannon, J. Hope;Jones, Alan E.;Trzeciak, Stephen
实验室研究表明，心脏骤停复苏后暴露于高氧环境可能会加重缺氧性脑损伤;目的验证复苏后高氧与死亡率增加相关的假设。设计，设置，使用重症监护病房（ICU）项目IMPACT重症监护数据库的患者多中心队列研究在2001年到2005年之间在120家美国医院进行了实验。患者入选标准为年龄大于17岁，非创伤性心脏骤停，抵达ICU前24小时内进行心肺复苏，抵达ICU后24小时内进行动脉血气分析。根据在ICU获得的首次动脉血气值的PaO 2将患者分为3组。高氧定义为PaO 2 ≥ 300 mm Hg;缺氧，PaO 2低于60 mm Hg（或PaO 2与吸入氧分数的比值
Context Laboratory investigations suggest that exposure to hyperoxia after resuscitation from cardiac arrest may worsen anoxic brain injury; however, clinical data are lacking.Objective To test the hypothesis that postresuscitation hyperoxia is associated with increased mortality.Design, Setting, and Patients Multicenter cohort study using the Project IMPACT critical care database of intensive care units (ICUs) at 120 US hospitals between 2001 and 2005. Patient inclusion criteria were age older than 17 years, nontraumatic cardiac arrest, cardiopulmonary resuscitation within 24 hours prior to ICU arrival, and arterial blood gas analysis performed within 24 hours following ICU arrival. Patients were divided into 3 groups defined a priori based on PaO2 on the first arterial blood gas values obtained in the ICU. Hyperoxia was defined as PaO2 of 300 mm Hg or greater; hypoxia, PaO2 of less than 60 mm Hg (or ratio of PaO2 to fraction of inspired oxygen