Reflection impulsivity and response inhibition in first-episode psychosis: relationship to cannabis use
Reflection impulsivity and response inhibition in first-episode psychosis: relationship to cannabis use
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DOI：
10.1017/s0033291712003054
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发表时间：
2013-10-01
影响因子：
6.9
通讯作者：
Joyce, E. M.
中科院分区：
文献类型：
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作者：
Huddy, V. C.;Clark, L.;Joyce, E. M.
背景精神病患者在停止信号任务（SST）中表现出受损的反应抑制。目前尚不清楚这种损害是否延伸到反射冲动，一种与非精神病样本中物质使用有关的冲动形式。我们比较了49例首发精神病（FEP）患者和30名健康对照参与者的两种形式的冲动使用信息抽样测试（IST）和SST，沿着临床和智商评估。我们还比较了那些使用大麻的患者与那些放弃或从未使用过大麻的患者。与健康对照组相比，FEP患者在反应抑制方面有显著更大的损害，但在反射冲动方面没有。相比之下，报告目前使用大麻的患者表现出更大的反射冲动比那些放弃或从未使用，而没有差异的反应抑制。这些数据表明，异常反射冲动与精神病中的物质使用有关，但与精神病本身无关;相反的关系可能适用于反应抑制。
Background. People with psychosis demonstrate impaired response inhibition on the Stop Signal Task (SST). It is less clear if this impairment extends to reflection impulsivity, a form of impulsivity that has been linked to substance use in non-psychotic samples.Method. We compared 49 patients with first-episode psychosis (FEP) and 30 healthy control participants on two forms of impulsivity measured using the Information Sampling Test (IST) and the SST, along with clinical and IQ assessments. We also compared those patients who used cannabis with those who had either given up or never used.Results. Patients with FEP had significantly greater impairment in response inhibition but not in reflection impulsivity compared with healthy controls. By contrast, patients who reported current cannabis use demonstrated greater reflection impulsivity than those that had either given up or never used, whereas there were no differences in response inhibition.Conclusions. These data suggest that abnormal reflection impulsivity is associated with substance use in psychosis but not psychosis itself; the opposite relationship may hold for response inhibition.