High-density vaginal Ureaplasma urealyticum colonization as a risk factor for chorioamnionitis and preterm delivery
High-density vaginal Ureaplasma urealyticum colonization as a risk factor for chorioamnionitis and preterm delivery
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DOI：
10.1034/j.1600-0412.2000.079011973.x
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发表时间：
2000-11-01
影响因子：
4.3
通讯作者：
Kolben, M
中科院分区：
文献类型：
--
作者：
Abele-Horn, M;Scholz, M;Kolben, M
背景本病例对照研究的目的是探讨生殖道解脲脲原体定植对妊娠结局的影响。172名妇女与解脲脲原体定植没有共存的其他感染和123名妇女与解脲脲原体阴性培养入组。在多变量分析中，定量测定解脲脲原体定殖水平的影响。与阴性妇女相比，解脲脲原体定植增加与出生体重（p < 0.0001）和胎龄（p < 0.0001）显著降低相关，与绒毛膜炎（p < 0.0001）和早产（p < 0.001）显著增加相关。在多变量分析中，高密度解脲脲原体定植是绒毛膜炎和早产的独立危险因素，而低定植水平对妊娠不良结局无影响。解脲脲原体的定植程度与对妊娠结局的不良影响密切相关。
background The aim of this case control study was to investigate the influence of genital Ureaplasma urealyticum colonization on pregnancy outcome.Methods. One hundred and seventy-two women colonized with Ureaplasma urealyticum without co-existing other infections and 123 women with negative cultures for Ureaplasma urealyticum were enrolled. In a multivariate analysis the influence of quantitative Ureaplasma urealyticum colonization level was determined.Results. Compared to the negative women increasing colonization with Ureaplasma urealyticum was associated with a significant decrease of birth weight (p < 0.0001) and gestational age (p < 0.0001) and with a significant increase of chorioamnionitis (p < 0.0001) and preterm delivery (p < 0.001). In a multivariate analysis high-density Ureaplasma urealyticum colonization was an independent risk factor for chorioamnionitis and preterm delivery, whereas low colonization levels had no effect on an adverse outcome of pregnancy.Conclusions. The degree of colonization with Ureaplasma urealyticum correlates strongly with an adverse effect on pregnancy outcome.