Optimal Testing of Multiple Hypotheses with Common Effect Direction
Optimal Testing of Multiple Hypotheses with Common Effect Direction
复制标题
具有共同效应方向的多个假设的最优检验
DOI：
10.2139/ssrn.938950
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发表时间：
2008
期刊：
影响因子：
2.1
通讯作者：
Michael Wolf
中科院分区：
文献类型：
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作者：
R. Bittman;Joseph P. Romano;C. Vallarino;Michael Wolf
We present a theoretical basis for testing related endpoints. Typically, it is known how to construct tests of the individual hypotheses, and the problem is how to combine them into a multiple test procedure that controls the familywise error rate. Using the closure method, we emphasize the role of consonant procedures, from an interpretive as well as a theoretical viewpoint. Suprisingly, even if each intersection test has an optimality property, the overall procedure obtained by applying closure to these tests may be inadmissible. We introduce a new procedure, which is consonant and has a maximin property under the normal model. The results are then applied to PROactive, a clinical trial designed to investigate the effectiveness of a glucose-lowering drug on macrovascular outcomes among patients with type 2 diabetes.
DOI：
--
发表时间：
1972
期刊：
--
影响因子：
--
作者：
D. Cox
通讯作者：
D. Cox