Spontaneous Neurotransmitter Release Shapes Dendritic Arbors via Long-Range Activation of NMDA Receptors.
Spontaneous Neurotransmitter Release Shapes Dendritic Arbors via Long-Range Activation of NMDA Receptors.
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DOI：
10.1016/j.celrep.2015.01.032
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发表时间：
2015-02-17
期刊：
影响因子：
8.8
通讯作者：
Burrone J
中科院分区：
文献类型：
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作者：
Andreae LC;Burrone J
自发性神经递质释放是成熟神经元中突触通讯的核心要素，但是尽管在发育中的轴突中发生异常高水平的自发性囊泡循环，但在此期间对其功能知之甚少。我们现在表明，高水平的，自发的轴突释放的神经递质谷氨酸可以在长距离的信号发育树突上的NMDA受体，突触形成之前，事实上，axodendritic接触。阻断NMDA信号在这个早期的自发囊泡循环导致减少树突状乔木的复杂性，表明早期自发释放在树突状乔木生长的重要作用。自发性神经递质释放在树突形成中的新作用囊泡状谷氨酸可以激活远端的“远程”树突NMDA受体突触前和突触后机制在突触接触之前运作自发性谷氨酸释放可以提供局部树突引导或分支线索自发性神经递质释放是成熟神经元突触通讯的核心要素，但其在神经元发育过程中的功能知之甚少。Andrant和Burrone现在表明，自发的谷氨酸释放在突触形成之前发挥了特定的作用，以控制树突状乔木的形成，通过NMDA受体的“长距离”激活发出信号。
Spontaneous neurotransmitter release is a core element of synaptic communication in mature neurons, but despite exceptionally high levels of spontaneous vesicle cycling occurring in developing axons, little is known of its function during this period. We now show that high-level, spontaneous axonal release of the neurotransmitter glutamate can signal at long range to NMDA receptors on developing dendrites, prior to synapse formation and, indeed, axodendritic contact. Blockade of NMDA signaling during this early period of spontaneous vesicle cycling leads to a reduction in dendritic arbor complexity, indicating an important role for early spontaneous release in dendritic arbor growth. New role for spontaneous neurotransmitter release in dendritic arbor formation Vesicular glutamate can activate distant “long-range” dendritic NMDA receptors Presynaptic and postsynaptic machinery operate before synaptic contact Spontaneous glutamate release may provide local dendritic guidance or branching cue Spontaneous neurotransmitter release is a core element of synaptic communication in mature neurons, but little is known of its function during neuronal development. Andreae and Burrone now show that spontaneous glutamate release exerts a specific role prior to synapse formation to control dendritic arbor formation, signaling via “long-range” activation of NMDA receptors.