Injection molding for manufacturing of solid poly(l-lactide-co-glycolide) microneedles
Injection molding for manufacturing of solid poly(l-lactide-co-glycolide) microneedles
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DOI：
10.1557/s43580-021-00030-3
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发表时间：
2021-02
期刊：
影响因子：
0.8
通讯作者：
Andrew Sachan;R. Sachan;Junqi Lu;Huiying Sun;Yingai Jin;D. Erdmann;Jennifer Y. Zhang;R. Narayan
中科院分区：
文献类型：
--
作者：
Andrew Sachan;R. Sachan;Junqi Lu;Huiying Sun;Yingai Jin;D. Erdmann;Jennifer Y. Zhang;R. Narayan
固体微针阵列可用于药物的“戳和流”经皮递送，其涉及药物通过由微针阵列产生的皮肤中的孔的输注或扩散。在本文中，使用注射成型由聚合物RESOMER LG 855 S-聚（l-丙交酯-共-乙交酯）产生固体微针阵列。扫描电子显微镜显示，注射成型的四乘一微针阵列中的微针与用于注射成型的尺寸紧密匹配。X射线光电子能谱显示，微针材料中的碳键合与聚（l-丙交酯-共-乙交酯）的预期相匹配。注意到微针材料的弹性模量降低为6.04 ± 0.17 GPa，适用于皮肤穿透应用。微针阵列用于将模型药物甲基蓝递送到手术丢弃的人腋下皮肤。这些结果表明，RESOMER LG 855 S-聚（l-丙交酯-共-乙交酯）的注射成型可能是大规模制造固体微针的适当方法。
A solid microneedle array can be used for “poke and flow” transdermal delivery of a drug, which involves the infusion or diffusion of a drug through pores in the skin that were created by the microneedle array. In this paper, solid microneedle arrays were created out of the polymer RESOMER LG 855 S—poly(l-lactide-co-glycolide) using injection molding. Scanning electron microscopy revealed that the microneedle in the injection-molded four-by-one microneedle array closely matched the dimensions that were used for injection molding. X-ray photoelectron spectroscopy revealed that the carbon bonding in the microneedle material matched that expected for poly(l-lactide-co-glycolide). The reduced elastic modulus of the microneedle material, 6.04 ± 0.17 GPa, was noted to be appropriate for skin penetration applications. The microneedle array was used for the delivery of the model drug methyl blue to surgically discarded human underarm skin. These results suggest that injection molding of RESOMER LG 855 S—poly(l-lactide-co-glycolide) may be an appropriate approach for large-scale manufacturing of solid microneedles.