Diabetes is a risk factor for the progression and prognosis of COVID-19
Diabetes is a risk factor for the progression and prognosis of COVID-19
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糖尿病是 COVID-19 进展和预后的危险因素
DOI：
10.1002/dmrr.3319
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发表时间：
2020-04-07
影响因子：
8
通讯作者：
Hu, Desheng
中科院分区：
文献类型：
--
作者：
Guo, Weina;Li, Mingyue;Hu, Desheng
背景了解糖尿病是否是影响2019年新型冠状病毒病（COVID-19）进展和预后的危险因素。方法对连续174例新冠肺炎确诊患者进行分析。收集和分析患者的人口统计资料、病史、症状和体征、实验室检查结果、胸部计算机断层扫描（CT）以及治疗措施。结果我们发现，无其他合并症但合并糖尿病的COVID-19患者（n = 24）发生严重肺炎、组织损伤相关酶释放、过度不受控制的炎症反应和糖代谢失调相关的高凝状态的风险较高。此外，糖尿病患者的血清炎症相关生物标志物如IL-6、c反应蛋白、血清铁蛋白和凝血指数d -二聚体水平显著高于非糖尿病患者（P < 0.01），表明糖尿病患者更容易发生炎症风暴，最终导致COVID-19快速恶化。我们的数据支持糖尿病应被视为COVID-19快速进展和不良预后的危险因素的观点。对糖尿病患者应给予更多的关注，以防病情迅速恶化。
Backgound To figure out whether diabetes is a risk factor influencing the progression and prognosis of 2019 novel coronavirus disease (COVID-19).Methods A total of 174 consecutive patients confirmed with COVID-19 were studied. Demographic data, medical history, symptoms and signs, laboratory findings, chest computed tomography (CT) as well the treatment measures were collected and analysed.Results We found that COVID-19 patients without other comorbidities but with diabetes (n = 24) were at higher risk of severe pneumonia, release of tissue injury-related enzymes, excessive uncontrolled inflammation responses and hypercoagulable state associated with dysregulation of glucose metabolism. Furthermore, serum levels of inflammation-related biomarkers such as IL-6, C-reactive protein, serum ferritin and coagulation index, D-dimer, were significantly higher (P < .01) in diabetic patients compared with those without, suggesting that patients with diabetes are more susceptible to an inflammatory storm eventually leading to rapid deterioration of COVID-19.Conclusions Our data support the notion that diabetes should be considered as a risk factor for a rapid progression and bad prognosis of COVID-19. More intensive attention should be paid to patients with diabetes, in case of rapid deterioration.