ISCHEMIC HEART-DISEASE SECONDARY TO AMYLOIDOSIS OF INTRAMYOCARDIAL ARTERIES
ISCHEMIC HEART-DISEASE SECONDARY TO AMYLOIDOSIS OF INTRAMYOCARDIAL ARTERIES
复制标题
DOI：
10.1016/0002-9149(79)90389-8
复制
发表时间：
1979-01-01
影响因子：
2.8
通讯作者：
HUTCHINS, GM
中科院分区：
文献类型：
--
作者：
SMITH, RRL;HUTCHINS, GM
在1889年至1977年尸检的108例心脏淀粉样变性患者中，有5例（4.6%）心肌内动脉有严重的闭塞性淀粉样沉积。所有5例患者的心脏均显示局灶性内膜下缺血性损伤，供应这些区域的血管被淀粉样蛋白完全或接近完全闭塞。临床上，4名患者患有充血性心力衰竭;其中1名患者还患有心律失常，1名患者患有心绞痛。缺血性心脏病的临床和病理特征均不能归因于心外膜冠状动脉疾病。心肌内动脉的淀粉样变性似乎能够产生局部缺血性坏死，并可能由于多个区域的缺血性损伤而产生顽固性充血性心力衰竭。
Among 108 patients with cardiac amyloidosis studied at autopsy between 1889 and 1977 there were 5 (4.6 percent) with severe occlusive amyloid deposits in intramyocardial arteries. The hearts of all five patients showed focal subendocardial ischemic injury, and the vessels supplying these areas had either complete or near complete luminal obliteration by amyloid. Clinically, four patients had congestive heart failure; one of these patients also had arrhythmias and one had angina pectoris. Neither the clinical nor the pathologic features of ischemic heart disease could be attributed to disease of the epicardial coronary arteries. Amyloidosis of the intramyocardial arteries appears to be capable of producing localized areas of ischemic necrosis and may produce intractable congestive heart failure due to multiple areas of ischemic injury.