Direct fluorescence visualization of clinically occult high-risk oral premalignant disease using a simple hand-held device
Direct fluorescence visualization of clinically occult high-risk oral premalignant disease using a simple hand-held device
复制标题
DOI：
10.1002/hed.20468
复制
发表时间：
2007-01-01
影响因子：
2.9
通讯作者：
Rosin, Miriam P.
中科院分区：
文献类型：
--
作者：
Poh, Catherine F.;Ng, Samson P.;Rosin, Miriam P.
背景相当一部分口腔癌和癌前病变在临床上并不明显，这可能导致口腔癌的晚期诊断和高死亡率。需要一种简单的方法来识别这种隐匿性变化。不列颠哥伦比亚省口腔发育不良诊所的患者目前正在使用一种简单的手持设备进行检查，该设备允许直接观察口腔中自体荧光的变化。对自发荧光消失的组织进行活检，结果。我们提出了3例有代表性的病例，在纵向随访中，我们通过荧光显像发现了隐匿性病变，结果病例1诊断为原发性异型增生，病例2诊断为第二原发性癌，病例3诊断为癌复发。这是第一次报告的诊断隐匿性口腔疾病使用一个简单的非侵入性设备。这些早期的例子表明了该技术在指导口腔病变患者管理方面的潜在价值，有助于检测白光可视化不明显的高风险变化。(c)2006 Wiley Periodicals，Inc.
Background. A considerable proportion of oral cancer and precancer is not clinically apparent and could contribute significantly to the late diagnosis and high mortality of oral cancer. A simple method to identify such occult change is needed.Methods. Patients in the Oral Dysplasia Clinics at British Columbia are currently being examined with a simple hand-held device that permits the direct visualization of alterations to auto-fluorescence in the oral cavity. Tissue showing loss of autofluorescence is biopsied,Results. We present 3 representative cases in which occult lesions we-e identified with fluorescence visualization during longitudinal follow-up, resulting in the diagnosis of a primary dysplasia in case 1, a second primary cancer in case 2, and cancer recurrence in case 3.Conclusions. This is the first report of the diagnosis of occult oral disease using a simple noninvasive device. These early examples indicate the potential value of this technology to guide the management of patients with oral lesions, facilitating the detection of high-risk changes not apparent with white-light visualization. (c) 2006 Wiley Periodicals, Inc.