Age at menopause, body mass index, and the risk of colorectal cancer mortality in the Dutch Diagnostisch Onderzoek Mammacarcinoom (DOM) cohort
Age at menopause, body mass index, and the risk of colorectal cancer mortality in the Dutch Diagnostisch Onderzoek Mammacarcinoom (DOM) cohort
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DOI：
10.1097/00001648-200005000-00013
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发表时间：
2000-05-01
期刊：
影响因子：
5.4
通讯作者：
Peeters, PHM
中科院分区：
文献类型：
--
作者：
van Wayenburg, CAM;van der Schouw, YT;Peeters, PHM
我们调查了绝经年龄是否与结直肠癌的后续死亡率沿着，以及体重指数对这种关联的可能修正。我们的数据来自荷兰的10，671名绝经后妇女的Diagnostisch Onderzoek Mammacarcinoom队列，1974年至1977年期间入组，中位随访时间为18年。在这次随访中，95名妇女死于结直肠癌。49岁或以上绝经期妇女结直肠癌死亡率低于49岁以下绝经期妇女。然而，这种保护作用仅在非超重女性（小于或等于24 kg/m2）中发现，其风险比为0.46（95%置信区间= 0.21-1.03）。在体型较大的女性中，风险比为1.17（95%置信区间= 0.68-2-.00）。
We investigated whether age at menopause is associated with subsequent mortality from colorectal cancer along with the possible modification of this association by body mass index. Our data are from the Diagnostisch Onderzoek Mammacarcinoom cohort of 10,671 postmenopausal women in the Netherlands, enrolled between 1974 and 1977, with a median follow-up of 18 years. During this follow-up, 95 women died of colorectal cancer. Women 49 years of age or older at menopause showed a lower risk of colorectal cancer mortality compared with women younger than 49 at menopause. This protective effect, however, was found only among nonoverweight women (less than or equal to 24 kg/m(2)), fur whom the hazard ratio was 0.46 (95% confidence interval = 0.21-1.03). In larger women, the hazard ratio was 1.17 (95% confidence interval = 0.68-2-.00).