Interleukin-10 serum levels and systemic endothelial vasoreactivity in patients with coronary artery disease
Interleukin-10 serum levels and systemic endothelial vasoreactivity in patients with coronary artery disease
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DOI：
10.1016/j.jacc.2004.02.054
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发表时间：
2004-07-07
影响因子：
24
通讯作者：
Zeiher, AM
中科院分区：
文献类型：
--
作者：
Fichtlscherer, S;Breuer, S;Zeiher, AM
由于内皮是炎症细胞因子的主要靶点，我们研究了冠状动脉疾病（CAD）患者血清白细胞介素(IL)-10水平升高是否与内皮血管反应性改善相关。背景：慢性炎症在动脉粥样硬化的进展中起关键作用。白细胞介素-10是一种抗炎细胞因子，对实验动物动脉粥样硬化病变的发展具有重要的保护作用。方法采用静脉闭塞容积描记术，通过测量内皮依赖性（乙酰胆碱[ACh] 10 ~ 50马克杯/分钟）和内皮非依赖性（硝基普钠[SNP] 2 ~ 8马克杯/分钟）前臂血流（FBF）反应，对65例男性冠心病患者的血管反应性进行评估。结果血清IL-10水平与乙酰胆碱诱导的FBF反应显著相关（r = 0.31, p < 0.02），但与SNP反应无显著相关性。重要的是，如果c反应蛋白（CRP）水平升高的患者血清IL-10水平升高，则未观察到乙酰胆碱刺激的FBF反应受损。在多因素分析中，包括低密度脂蛋白胆固醇、吸烟、高血压、糖尿病、患者临床状况、他汀类药物和/或血管紧张素转换酶抑制剂治疗，只有IL-10 （p < 0.02）和CRP血清水平（p < 0.02）是ach诱导的FBF反应的显著独立预测因子。因此，血清中IL-10水平升高与CRP水平升高的患者全身内皮血管反应性改善相关，表明促炎介质和抗炎介质之间的平衡是CAD患者内皮功能的主要决定因素。(C) 2004年由美国心脏病学会基金会发布。
OBJECTIVES Because the endothelium is a major target for inflammatory cytokines, we investigated whether elevated interleukin (IL)-10 serum levels are associated with improved endothelial vasoreactivity in patients with coronary artery disease (CAD).BACKGROUND Chronic inflammation plays a pivotal role in the progression of atherosclerosis. Interleukin-10 is an anti-inflammatory cytokine that exerts important protective effects on atherosclerotic lesion development in experimental animals.METHODS Vasoreactivity was assessed in 65 male patients with documented CAD by measuring endothelium-dependent (acetylcholine [ACh] 10 to 50 mug/min) and endothelium-independent (sodium nitroprusside [SNP] 2 to 8 mug/min) forearm blood flow (FBF) responses using venous occlusion plethysmography.RESULTS Serum levels of IL-10 were significantly correlated with ACh-induced FBF responses (r = 0.31, p < 0.02), but not with SNP responses. Importantly, if IL-10 serum levels were increased in patients with elevated C-reactive protein (CRP) levels, no impairment of ACh-stimulated FBF response was observed. On multivariate analysis, including low-density lipoprotein cholesterol, smoking, hypertension, diabetes, clinical status of the patients, and statin and/or angiotensin-converting enzyme inhibitor treatment, only IL-10 (p < 0.02) and CRP serum levels (p < 0.02) were significant independent predictors of ACh-induced FBF responses.CONCLUSIONS Thus, increased IL-10 serum levels are associated with improved systemic endothelial vasoreactivity in patients with elevated CRP serum levels, demonstrating that the balance between pro- and anti-inflammatory mediators is a major determinant of endothelial function inpatients with CAD. (C) 2004 by the American College of Cardiology Foundation.