A gold standard set of mechanistically diverse enzyme superfamilies.
A gold standard set of mechanistically diverse enzyme superfamilies.
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DOI：
10.1186/gb-2006-7-1-r8
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发表时间：
2006
期刊：
影响因子：
12.3
通讯作者：
Babbitt, Patricia C
中科院分区：
文献类型：
--
作者：
Brown, Shoshana D;Gerlt, John A;Seffernick, Jennifer L;Babbitt, Patricia C
一个金标准的酶超家族，根据序列，结构和功能标准进行聚类。超家族和家族分析为蛋白质的功能分类提供了有效的工具，但必须自动化用于大型数据集。我们描述了一个“金标准”的酶超家族，聚类根据特定的序列，结构和功能的标准，用于家庭和超家族聚类方法的验证。金标准集代表了四个折叠类和不同的聚类难度，包括5个超家族，91个家族，4，887个序列和282个结构。
A gold standard set of enzyme superfamilies, clustered according to sequence, structure and functional criteria, is presented. Superfamily and family analyses provide an effective tool for the functional classification of proteins, but must be automated for use on large datasets. We describe a 'gold standard' set of enzyme superfamilies, clustered according to specific sequence, structure, and functional criteria, for use in the validation of family and superfamily clustering methods. The gold standard set represents four fold classes and differing clustering difficulties, and includes five superfamilies, 91 families, 4,887 sequences and 282 structures.