BRCA mutation testing in determining breast cancer therapy.
BRCA mutation testing in determining breast cancer therapy.
复制标题
BRCA 基因突变检测在确定乳腺癌治疗中的作用。
DOI：
10.1097/ppo.0b013e318238f579
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发表时间：
2011-11
期刊：
影响因子：
--
通讯作者：
Isaacs C
中科院分区：
文献类型：
--
作者：
Smith KL;Isaacs C
BRCA-mutation associated breast cancer differs from sporadic breast cancer with regard to future cancer risks and sensitivity to systemic therapies. Now that rapid genetic testing for BRCA1 and BRCA2 mutations is available at the time of breast cancer diagnosis, BRCA mutation status can be considered when making treatment and prevention decisions for BRCA mutation carriers with breast cancer. This article reviews surgical options for management of affected BRCA mutation carriers with emphasis on the risks of ipsilateral recurrence and contralateral breast cancer. The roles of breast conserving surgery, prophylactic mastectomy and oophorectomy are reviewed. In addition, sensitivity of BRCA mutation-associated breast cancer to endocrine therapy, platinum chemotherapy and poly (ADP-Ribose) polymerase inhibitors is reviewed.
