Inositol 1,3,4-Trisphosphate 5/6-Kinase Is a Protein Kinase That Phosphorylates the Transcription Factors c-Jun and ATF-2*
Inositol 1,3,4-Trisphosphate 5/6-Kinase Is a Protein Kinase That Phosphorylates the Transcription Factors c-Jun and ATF-2*
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DOI：
10.1074/jbc.m106605200
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发表时间：
2001-11
期刊：
影响因子：
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通讯作者：
Monita P. Wilson;Yang Sun;Li Cao;P. Majerus
中科院分区：
文献类型：
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作者：
Monita P. Wilson;Yang Sun;Li Cao;P. Majerus
肌醇1,3,4-三磷酸被肌醇1,3,4-三磷酸5/6激酶磷酸化是形成更高磷酸化形式的肌醇的第一步。我们已经证明了八种称为COP9信号体复合物的蛋白质与小牛脑5/6激酶共化。由于该复合物已被证明能在体外磷酸化c-Jun，我们测试了该复合物和5/6-激酶，发现两者都能磷酸化c-Jun和ATF-2的丝氨酸/苏氨酸残基。这些发现建立了两个主要信号转导系统之间的联系：肌醇磷酸酯和应激反应系统。
Phosphorylation of inositol 1,3,4-trisphosphate by inositol 1,3,4-trisphosphate 5/6-kinase is the first committed step in the formation of higher phosphorylated forms of inositol. We have shown that the eight proteins called the COP9 signalosome complex copurify with calf brain 5/6-kinase. Because the complex has been shown to phosphorylate c-Jun in vitro, we tested both the complex and 5/6-kinase and found that both are able to phosphorylate c-Jun and ATF-2 on serine/threonine residues. These findings establish a link between two major signal transduction systems: the inositol phosphates and the stress response system.