Mean cortical curvature reflects cytoarchitecture restructuring in mild traumatic brain injury.
Mean cortical curvature reflects cytoarchitecture restructuring in mild traumatic brain injury.
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DOI：
10.1016/j.nicl.2016.01.003
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Yurgelun-Todd DA
中科院分区：
文献类型：
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作者：
King JB;Lopez-Larson MP;Yurgelun-Todd DA
仅在美国，患有创伤性脑损伤持久后果的人数估计在320万至500万之间。这一数字不包括在美国军队服役或在退伍军人事务部医院寻求护理的个人。了解轻度创伤性脑损伤（mTBI）的神经生物学后果的重要性随着退伍军人从海外冲突中返回而增加，其中许多人遭受了这种类型的脑损伤。然而，识别受mTBI影响最大的神经解剖区域仍然具有挑战性。本研究的目的是评估使用平均皮质曲率作为一个潜在的指标进行性组织损失的横截面样本的54名退伍军人与mTBI相比，31名对照组进行MRI评价。据推测，与对照组相比，mTBI退伍军人的平均皮质曲率会增加，部分原因是与组织体积损失相关的皮质重建。在60个双侧区域（31个脑沟，29个脑回）中评估了平均皮质曲率。在所研究的120个区域中，相对于对照，近50%的mTBI表现出显著增加的平均皮质曲率，其中25%在多重比较校正后保持显著性（所有，pFDR <0.05）。这些差异在皮质的深层灰质区域最为突出。此外，在平均皮质曲率与灰色和白色物质体积之间发现了显著的关系（所有，p <0.05）。这些发现表明，潜在的独特的萎缩模式的区域，并表明，由于mTBI的大脑微结构的变化是敏感的平均曲率的措施。平均皮质曲率用于评估皮质的mTBI相关变化。相对于对照组，mTBI中广泛皮质区域的曲率增加。脑回和脑沟的曲率增加与脑容量差异有关。
In the United States alone, the number of persons living with the enduring consequences of traumatic brain injuries is estimated to be between 3.2 and 5 million. This number does not include individuals serving in the United States military or seeking care at Veterans Affairs hospitals. The importance of understanding the neurobiological consequences of mild traumatic brain injury (mTBI) has increased with the return of veterans from conflicts overseas, many of who have suffered this type of brain injury. However, identifying the neuroanatomical regions most affected by mTBI continues to prove challenging. The aim of this study was to assess the use of mean cortical curvature as a potential indicator of progressive tissue loss in a cross-sectional sample of 54 veterans with mTBI compared to 31 controls evaluated with MRI. It was hypothesized that mean cortical curvature would be increased in veterans with mTBI, relative to controls, due in part to cortical restructuring related to tissue volume loss. Mean cortical curvature was assessed in 60 bilateral regions (31 sulcal, 29 gyral). Of the 120 regions investigated, nearly 50% demonstrated significantly increased mean cortical curvature in mTBI relative to controls with 25% remaining significant following multiple comparison correction (all, pFDR < .05). These differences were most prominent in deep gray matter regions of the cortex. Additionally, significant relationships were found between mean cortical curvature and gray and white matter volumes (all, p < .05). These findings suggest potentially unique patterns of atrophy by region and indicate that changes in brain microstructure due to mTBI are sensitive to measures of mean curvature. Mean cortical curvature was used to assess mTBI related changes to the cortex. Curvature was increased in widespread cortical regions in mTBI relative to controls. Increased curvature was linked with brain volumes differentially in gyri and sulci.