Sleep homeostasis and cortical synchronization: III. A high-density EEG study of sleep slow waves in humans
Sleep homeostasis and cortical synchronization: III. A high-density EEG study of sleep slow waves in humans
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DOI：
10.1093/sleep/30.12.1643
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发表时间：
2007-12-01
期刊：
影响因子：
5.6
通讯作者：
Tononi, Giulio
中科院分区：
文献类型：
--
作者：
Riedner, Brady A.;Vyazovskiy, Vladyslav V.;Tononi, Giulio
研究目标：睡眠期间慢波活动（SWA，在本研究中定义为 0.5 至 4.0 Hz 之间的脑电图 [EEG] 功率）稳态下降的机制尚不清楚。与最近的假设一致，在 3 篇配套论文中的第一篇中，对睡眠丘脑皮质系统的大规模计算机模拟表明，皮质突触强度的下降足以解释 SWA 的下降。在模型中，SWA 的减少伴随着高振幅慢波发生率的减少、波斜率的降低以及多峰波数量的增加。在大鼠的第二篇配套论文中，早期和晚期睡眠期间的局部场电位记录证实了该模型的预测。(4) 在这里，我们通过使用整夜高密度 (hd)-EEG 记录探索整个皮层地幔的慢波参数，研究了模型对人类的预测。设计：人类整个晚上睡眠过程中的 256 通道 EEG 记录。设置：声音衰减睡眠研究室患者或参与者：7健康男性受试者干预措施：不适用。测量和结果：在晚睡期间（非快速眼动 [NREM] 第 3 和 4 期，接近早晨），与早期睡眠（NREM 睡眠第 1 期和第 2 期，夜间开始时）相比，分析显示 (1) SWA 减少，(2) 大振幅慢波减少，(3) 波斜率降低，(4) 多峰波更频繁。即使当波与背景脑电图中的波幅和慢波功率直接匹配时，早睡和晚睡之间的斜率也会降低。最后，高清脑电图显示多峰波具有多个皮质起源。结论：在人类脑电图中，睡眠期间 SWA 的下降伴随着慢波参数的变化，这是由模拟皮质突触强度稳态降低的计算机模型预测的。
Study Objectives: The mechanisms responsible for the homeostatic decrease of slow-wave activity (SWA, defined in this study as electroencephalogram [EEG] power between 0.5 and 4.0 Hz) during sleep are unknown. In agreement with a recent hypothesis, in the first of 3 companion papers, large-scale computer simulations of the sleeping thalamocortical system showed that a decrease in cortical synaptic strength is sufficient to account for the decline in SWA. In the model, the reduction in SWA was accompanied by decreased incidence of high-amplitude slow waves, decreased wave slopes, and increased number of waves with multiple peaks. In a second companion paper in the rat, local field potential recordings during early and late sleep confirmed the predictions of the model.(4) Here, we investigated the model's predictions in humans by using all-night high-density (hd)-EEG recordings to explore slow-wave parameters over the entire cortical mantle.Design: 256-channel EEG recordings in humans over the course of an entire night's sleep.Setting: Sound-attenuated sleep research roomPatients or Participants: Seven healthy male subjectsInterventions: N/A.Measurements and Results: During late sleep (non-rapid eye movement [NREM] episodes 3 and 4, toward morning), when compared with early sleep (NREM sleep episodes I and 2, at the beginning of the night), the analysis revealed (1) reduced SWA, (2) fewer large-amplitude slow waves, (3) decreased wave slopes, (4) more frequent multipeak waves. The decrease in slope between early and late sleep was present even when waves were directly matched by wave amplitude and slow-wave power in the background EEG. Finally, hd-EEG showed that multipeak waves have multiple cortical origins.Conclusions: In the human EEG, the decline of SWA during sleep is accompanied by changes in slow-wave parameters that were predicted by a computer model simulating a homeostatic reduction of cortical synaptic strength.