Preparation of potassium alkoxymethyltrifluoroborates and their cross-coupling with aryl chlorides
Preparation of potassium alkoxymethyltrifluoroborates and their cross-coupling with aryl chlorides
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DOI：
10.1021/ol800532p
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发表时间：
2008-06-05
期刊：
影响因子：
5.2
通讯作者：
Canturk, Belgin
中科院分区：
文献类型：
--
作者：
Molander, Gary A.;Canturk, Belgin
采用S(N)2取代溴甲基三氟硼酸钾，制备了多种醇氧基三氟硼酸烷氧基甲基三氟硼酸盐底物，收率高。这些烷氧甲基三氟硼酸盐与几种芳酰氯有效地交叉偶联。这种方法提供了一个独特的不和谐断开，允许更大的灵活性设计新的和改进的合成途径。
A wide variety of alkoxymethyltrifluoroborate substrates were prepared via S(N)2 displacement of potassium bromomethyltrifluoroborate with various alkoxides in excellent yields. These alkoxymethyltrifluoroborates were effectively cross-coupled with several aryl chlorides. This method provides a unique dissonant disconnect that allows greater flexibility in the design of new and improved synthetic pathways.