Beyond the conventional description of dynamic force spectroscopy of adhesion bonds
Beyond the conventional description of dynamic force spectroscopy of adhesion bonds
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DOI：
10.1073/pnas.1534554100
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发表时间：
2003-09-30
影响因子：
11.1
通讯作者：
Urbakh, M
中科院分区：
文献类型：
--
作者：
Dudko, OK;Filippov, AE;Urbakh, M
单分子的动态力谱是由一个模型，预测破裂力的分布，相应的平均破裂力，和方差，这都是服从实验测试。该分布具有明显的不对称性，这是最近在实验中观察到的。平均破裂力遵循（InV）（2/3）依赖于拉动速度，V，并不同于早期的预测。有趣的是，在低拉速下，获得了一个再结合过程，其特征是弹簧力的间歇性行为，这延迟了断裂。提出了一个扩展，包括构象变化的粘附复合物，这导致了双峰分布的断裂力的可能性。
Dynamic force spectroscopy of single molecules is described by a model that predicts a distribution of rupture forces, the corresponding mean rupture force, and variance, which are all amenable to experimental tests. The distribution has a pronounced asymmetry, which has recently been observed experimentally. The mean rupture force follows a (InV)(2/3) dependence on the pulling velocity, V, and differs from earlier predictions. Interestingly, at low pulling velocities, a rebinding process is obtained whose signature is an intermittent behavior of the spring force, which delays the rupture. An extension to include conformational changes of the adhesion complex is proposed, which leads to the possibility of bimodal distributions of rupture forces.