Estrogen receptor, progesterone receptor, and Her 2 Neu positivity and its association with tumour characteristics and menopausal status in a breast cancer cohort from northern Pakistan.
Estrogen receptor, progesterone receptor, and Her 2 Neu positivity and its association with tumour characteristics and menopausal status in a breast cancer cohort from northern Pakistan.
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DOI：
10.3332/ecancer.2012.283
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发表时间：
2012
影响因子：
1.8
通讯作者：
Irfan J
中科院分区：
文献类型：
--
作者：
Faheem M;Mahmood H;Khurram M;Qasim U;Irfan J
旨在测量巴基斯坦北部乳腺癌队列中雌激素受体 (ER)、孕激素受体 (PR) 和 Her 2 Neu 阳性的频率，并研究它们与肿瘤特征和绝经状态的关联。在提供知情同意后，参加 NORI 并经组织病理学证明诊断为乳腺浸润性导管癌的患者被纳入。记录年龄、绝经状态和肿瘤大小。记录是否存在淋巴结受累（包括部位和数量）、远处转移、转移部位、皮肤受累、胸壁受累、复发性疾病和双侧乳腺癌，以及 ER、PR 和 Her 2 Neu 状态。计算年龄等连续变量的平均值±标准差。计算 ER、PR 和 Her 2 Neu 状态等分类变量的频率和百分比。在适当的情况下，采用 t 检验、x2 平方检验和方差分析来寻找 ER、PR 和 Her 2 Neu 状态与绝经状态和肿瘤相关特征的关联。 P值>0.05被认为是显着的。该研究共有 1226 名患者。患者平均年龄为 48.04 ± 11.97 岁，743 名 (60.6%) 患者处于绝经前。 ER、PR 和 Her 2 Neu 分别在 763 名 (62.2%)、738 名 (60.1%) 和 478 名 (38.9%) 患者中呈阳性。 ER、PR 阳性和 Her 2 Neu 过度表达与绝经状态、肿瘤大小、皮肤、胸壁和淋巴结受累以及远处转移的存在存在显着相关性 (P < 0.05)。然而，ER、PR、Her 2 Neu 和复发性疾病之间没有发现显着关联。来自巴基斯坦北部的乳腺癌患者中激素受体的表达频率与文献报道的相同，尽管 Her 2 Neu 的过度表达在我们的人群中略高一些。激素受体表达与 Her 2 Neu 表达之间存在反比关系。绝经后女性 ER 和 PR 阳性以及 Her 2 Neu 阴性的发生率较高。 ER 和 PR 阴性以及 Her 2 Neu 阳性与更晚期的疾病和不良结果相关。
To measure the frequency of estrogen receptor (ER), progesterone receptor (PR), and Her 2 Neu positivity and to study their association with tumour characteristics and menopausal status in a breast cancer cohort from Northern Pakistan. Patients attending NORI with histopathologically proven diagnosis of invasive ductal carcinoma of the breast were included after providing informed consent. Age, menopausal status, and tumour size were recorded. The presence or absence of nodal involvement (including site and number), distant metastases, sites of metastases, skin involvement, chest wall involvement, recurrent disease, and bilateral breast cancer were noted along with ER, PR, and Her 2 Neu status. Mean ± standard deviations were calculated for continuous variables like age. Frequency and percentage were calculated for categorical variables like ER, PR, and Her 2 Neu status. Association of ER, PR, and Her 2 Neu status with menopausal status and tumour-related characteristics were sought employing t test, x2 square test, and ANOVA wherever appropriate. P value >0.05 was considered significant. There were 1226 patients included in the study. Mean patient age was 48.04 ± 11.97 years, and 743 (60.6%) patients were premenopausal. ER, PR, and Her 2 Neu were found positive in 763 (62.2%), 738 (60.1%), and 478 (38.9%) patients, respectively. Significant association (P < 0.05) was found between ER, PR positivity, and Her 2 Neu over expression with menopausal status, tumour size, involvement of skin, chest wall and lymph nodes and the presence of distant metastases. However, no significant association was detected between ER, PR, Her 2 Neu and recurrent disease. The frequency of expression of hormonal receptors in breast cancer patients from Northern Pakistan is the same as reported in the literature although overexpression of Her 2 Neu is a little higher in our population. There is an inverse relationship between hormonal receptors expression and Her 2 Neu expression. Postmenopausal women have a higher incidence of ER and PR positivity and Her 2 Neu negativity. ER and PR negativity and Her 2 Neu positivity are associated with more advanced disease and poor outcome.