Reductive amination as a strategy to reduce adenovirus vector promiscuity by chemical capsid modification with large polysaccharides
Reductive amination as a strategy to reduce adenovirus vector promiscuity by chemical capsid modification with large polysaccharides
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DOI：
10.1002/jgm.1262
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发表时间：
2008-12
期刊：
影响因子：
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通讯作者：
Sigrid Espenlaub;Andreas Wortmann;T. Engler;S. Corjon;S. Kochanek;F. Kreppel
中科院分区：
文献类型：
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作者：
Sigrid Espenlaub;Andreas Wortmann;T. Engler;S. Corjon;S. Kochanek;F. Kreppel
已显示用合成聚合物对腺病毒载体进行化学衣壳修饰有助于克服腺病毒载体介导的基因转移的典型障碍。迄今为止，用于共价修饰腺病毒载体的基于碳水化合物的聚合物在很大程度上被忽视。我们利用还原胺化策略来产生一类具有甘露聚糖衍生物的新型基于腺病毒的糖载体。
Chemical capsid modification of adenovirus vectors with synthetic polymers has been shown to aid in overcoming typical barriers for adenovirus vector‐mediated gene transfer. Carbohydrate‐based polymers for covalent modification of adenovirus vectors have been largely neglected so far. We utilized a reductive amination strategy to generate a novel class of adenovirus‐based glycovectors with a mannan derivative.