Familial resemblance for VO2max in the sedentary state:: the HERITAGE Family Study
Familial resemblance for VO2max in the sedentary state:: the HERITAGE Family Study
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DOI：
10.1097/00005768-199802000-00013
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发表时间：
1998-02-01
期刊：
影响因子：
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通讯作者：
Wilmore, JH
中科院分区：
文献类型：
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作者：
Bouchard, C;Daw, EW;Wilmore, JH
本研究基于参与HERITAGE家族研究的86个高加索血统核心家庭的数据，调查了最大摄氧量（Vover dotO(2max)）的家族相似性。在目前的研究中，429名年龄在16岁至65岁之间久坐不动的人（170名父母和259名子女）在一个循环测力仪上测量了两次Vover dotO（2max）。Vover dotO（2max）通过回归程序进行了调整，以考虑年龄和性别的影响；2)年龄、性别、体重；3)年龄、性别、体重、脂肪量和无脂肪量，由水下称重确定。在三种Vover dotO（2max）表型中均观察到显著的家族相似性。配偶、兄弟姐妹和父母后代的相关性显著，表明遗传和环境因素共同影响了Vover dot O-2max的家族相似性。最大遗传率估计至少为50%，这个值被非遗传因素夸大到一个不确定的程度。研究还发现，母亲遗传的假设，即父亲对环境的贡献，与母亲遗传的估计相吻合，可能部分与线粒体遗传有关，达到约30%。这些结果表明，遗传和非遗传因素以及母亲的影响有助于久坐个体中Vover dotO（2max）的家族聚集。
This study investigates the familial resemblance of maximal oxygen uptake (Vover dotO(2max)) based on data from 86 nuclear families of Caucasian descent participating in the HERITAGE Family Study. In the current study, Vover dotO(2max) was measured twice on a cycle ergometer in 429 sedentary individuals (170 parents and 259 of their offspring), aged between 16 and 65 yr. The Vover dotO(2max) was adjusted by regression procedures for the effects of 1) age and sex; 2) age, sex, and body mass; and 3) age, sex, body mass, fat mass, and fat-free mass, as determined by underwater weighing. Evidence for significant familial resemblance was observed for each of the three Vover dotO(2max) phenotypes. Spouse, sibling, and parent-offspring correlations were significant, suggesting that both genetic and environmental factors contribute to the familial resemblance for Vover dot O-2max. Maximal heritability estimates were at least 50%, a value inflated to an undetermined degree by nongenetic factors. The hypothesis of maternal inheritance, with the father's contribution being environmental, was also found to fit the data with estimates of maternal heritability, potentially associated in part with mitochondrial inheritance, reaching about 30%. These results suggest that genetic and nongenetic factors as well as maternal influences contribute to the familial aggregation of Vover dotO(2max) in sedentary individuals.