Sirt6 Deacetylase: A Potential Key Regulator in the Prevention of Obesity, Diabetes and Neurodegenerative Disease.
Sirt6 Deacetylase: A Potential Key Regulator in the Prevention of Obesity, Diabetes and Neurodegenerative Disease.
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Sirt6脱乙酰酶：预防肥胖、糖尿病和神经退行性疾病的潜在关键调节因子。
DOI：
10.3389/fphar.2020.598326
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发表时间：
2020
影响因子：
5.6
通讯作者：
Kanwal A
中科院分区：
文献类型：
--
作者：
Raj S;Dsouza LA;Singh SP;Kanwal A
Sirtuins是属于III类组蛋白去乙酰化酶的NAD +依赖性蛋白，参与调节许多细胞过程，包括细胞应激、胰岛素抵抗、炎症、线粒体生物合成、染色质沉默、细胞周期调节、转录和凋亡。在存在于人类中的七种哺乳动物sirtuin中，Sirt6是必需的核sirtuin。直到最近，Sirt6才被认为调节染色质沉默，但新的研究表明它在衰老，糖尿病，心血管疾病，脂质代谢，神经退行性疾病和癌症中的作用。各种鼠模型证明，Sirt6活化有益于缓解许多疾病状况和增加寿命，表明Sirt6是治疗人类各种疾病状况的关键治疗靶标。Sirt6还通过作用于组蛋白和非组蛋白来调节多种疾病的发病机制。内源性和非内源性调节剂调节Sirt6的激活和抑制。已经鉴定了很少的Sirt6特异性非内源性调节剂。因此，Sirt6特异性调节剂的鉴定可能在上述疾病中具有潜在的治疗作用。本文综述了Sirt6的研究进展，Sirt6在人类疾病中的作用，Sirt6在疾病过程中的功能作用和治疗意义，以及Sirt6在调节代谢稳态、心血管疾病、衰老和神经退行性疾病中的特异性调节剂和分子机制。
Sirtuins, NAD + dependent proteins belonging to class III histone deacetylases, are involved in regulating numerous cellular processes including cellular stress, insulin resistance, inflammation, mitochondrial biogenesis, chromatin silencing, cell cycle regulation, transcription, and apoptosis. Of the seven mammalian sirtuins present in humans, Sirt6 is an essential nuclear sirtuin. Until recently, Sirt6 was thought to regulate chromatin silencing, but new research indicates its role in aging, diabetes, cardiovascular disease, lipid metabolism, neurodegenerative diseases, and cancer. Various murine models demonstrate that Sirt6 activation is beneficial in alleviating many disease conditions and increasing lifespan, showing that Sirt6 is a critical therapeutic target in the treatment of various disease conditions in humans. Sirt6 also regulates the pathogenesis of multiple diseases by acting on histone proteins and non-histone proteins. Endogenous and non-endogenous modulators regulate both activation and inhibition of Sirt6. Few Sirt6 specific non-endogenous modulators have been identified. Hence the identification of Sirt6 specific modulators may have potential therapeutic roles in the diseases described above. In this review, we describe the development of Sirt6, the role it plays in the human condition, the functional role and therapeutic importance in disease processes, and specific modulators and molecular mechanism of Sirt6 in the regulation of metabolic homeostasis, cardiovascular disease, aging, and neurodegenerative disease.
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影响因子：
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作者：
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通讯作者：
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通讯作者：
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通讯作者：
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