The relationship between neighborhood socioeconomic deprivation and telomere length: The 1999-2002 National Health and Nutrition Examination Survey
The relationship between neighborhood socioeconomic deprivation and telomere length: The 1999-2002 National Health and Nutrition Examination Survey
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DOI：
10.1016/j.ssmph.2019.100517
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发表时间：
2020-04-01
影响因子：
4.7
通讯作者：
Davis, Sharon K.
中科院分区：
文献类型：
--
作者：
Powell-Wiley, Tiffany M.;Gebreab, Samson Y.;Davis, Sharon K.
社会经济上处于不利地位的社区与健康状况不佳有关。贫困的邻里环境对健康产生负面影响的生物学机制尚不清楚。利用1999-2002年全国健康与营养调查（NHANES）的数据，通过多层模型来评估邻里剥夺指数（NDI）和对数转化白细胞端粒长度（LTL）之间的关系，以控制人口普查水平的聚类。模型采用NDI （ref = low NDI）。NDI是使用2000年美国人口普查的普查区水平社会经济指标计算的。样本（n = 5106名成年人）中女性占49.8%，非西班牙裔白人占82.9%，非西班牙裔黑人占9.4%，墨西哥裔美国人占7.6%。平均年龄45.8岁。NDI高的社区居民较年轻，非白人，受教育程度较低，贫困收入比较低（均p < 0.0001）。在中等NDI （beta = 0.043, SE = 0.012, p = 0.0005）和高NDI （beta = 0.039, SE = 0.013, p = 0.003）社区中，邻里剥夺与LTL呈负相关。在男性中，中等（β = 0.042, SE = 0.015, p = 0.006）和高（β = 0.047, SE = 0.015, p = 0.001） NDI与较短的LTL相关。在女性中，只有中等NDI （β = 0.020, SE = 0.016, p = 0.009）与较短的LTL相关。在控制了个人特征（包括个人层面的社会经济地位）之后，在美国成年人的全国代表性样本中，社区社会经济剥夺的增加与较短的LTL有关。这表明端粒缩短可能是邻里剥夺导致健康状况不佳的一种机制。
Socioeconomically disadvantaged neighborhoods have been associated with poor health outcomes. Little is known about the biological mechanism by which deprived neighborhood conditions exert negative influences on health. Data from the 1999-2002 National Health and Nutrition Examination Surveys (NHANES) were used to assess the relationship between neighborhood deprivation index (NDI) and log-transformed leukocyte telomere length (LTL) via multilevel modeling to control for census tract level clustering. Models were constructed using tertiles of NDI (ref = low NDI). NDI was calculated using census tract level socioeconomic indicators from the 2000 U.S. Census. The sample (n = 5,106 adults) was 49.8% female and consisted of 82.9% non-Hispanic whites, 9.4% non-Hispanic blacks, and 7.6% Mexican Americans. Mean age was 45.8 years. Residents of neighborhoods with high NDI were younger, non-white, had lower educational attainment, and had a lower poverty to income ratio (all p < 0.0001). Neighborhood deprivation was inversely associated with LTL among individuals living in neighborhoods with medium NDI (beta = 0.043, SE = 0.012, p = 0.0005) and high NDI (beta = 0.039, SE = 0.013, p = 0.003). Among men, both medium (beta = 0.042, SE = 0.015, p = 0.006) and high (beta = 0.047, SE = 0.015, p = 0.001) NDI were associated with shorter LTL. Among women, only medium NDI (beta = 0.020, SE = 0.016, p = 0.009) was associated with shorter LTL. After controlling for individual characteristics, including individual-level socioeconomic status, increasing neighborhood socioeconomic deprivation is associated with shorter LTL among a nationally representative sample of US adults. This suggests that telomere shortening may be a mechanism through which neighborhood deprivation results in poor health outcomes.