Scalable Fabrication of PEGDA Microneedles Using UV Exposure via a Rotating Prism
Scalable Fabrication of PEGDA Microneedles Using UV Exposure via a Rotating Prism
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DOI：
10.1109/jmems.2017.2740177
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发表时间：
2017-10-01
影响因子：
2.7
通讯作者：
Shimoyama, I.
中科院分区：
文献类型：
--
作者：
Takahashi, H.;Heo, Y. J.;Shimoyama, I.
我们提出了一种简单，快速，高度可扩展，直接的方法来制造高度生物相容性的聚乙二醇二丙烯酸酯（PEGDA）微针。通过旋转棱镜施加紫外光，在PEGDA中形成针形分布的紫外（UV）曝光剂量。棱镜使UV光线弯曲，使得棱镜的底角确定光的倾斜角。因此，可以通过改变棱镜的底角来控制微针高度。我们实验证明了直接高度可伸缩的潜力。随着棱镜底角的增大，微针高度减小，微针尖端角增大。这些结果表明，微针的几何形状可以很容易地控制棱镜的底角，而无需额外的微加工。此外，与光致抗蚀剂微针不同，PEGDA不需要任何热烘烤，因此能够在短的工艺时间内形成良好定义的对称针。因此，本发明的方法可以促进PEGDA微针的实际应用。[2017- 01 - 36]
We propose a simple, fast, height-scalable, and direct way to fabricate highly biocompatible polyethylene glycol diacrylate (PEGDA) microneedles. A needle-shaped distribution of ultraviolet (UV) exposure dose is formed in PEGDA by applying UV light through a rotating prism. A prism makes UV light rays bend, such that the base angle of the prism determines the inclined angle of the light. Thus, the microneedle height can be controlled by varying the base angles of the prism. We experimentally demonstrate the direct height-scalable potential. The microneedle height decreases and the microneedle tip angle increases with increases in the base angle of the prism. These results indicate that the microneedle geometry can be easily controlled by the base angle of a prism without additional microfabrication. In addition, unlike photoresist microneedles, PEGDA does not require any thermal baking, thus enabling well-defined symmetric needle formation with short process time. Therefore, the present method can facilitate PEGDA microneedles to practical applications. [2017-0136]