Synthesis of β-Arylseleno Sulfoximines: A Metal-Free Three-Component Reaction Mediated by Tetrabutylammonium Tribromide.
Synthesis of β-Arylseleno Sulfoximines: A Metal-Free Three-Component Reaction Mediated by Tetrabutylammonium Tribromide.
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DOI：
10.1021/acs.joc.2c00880
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发表时间：
2022-08
期刊：
影响因子：
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通讯作者：
Xiaoman Li;Jiawei Huang;Liang Xu;Ping Liu;Yueting Wei
中科院分区：
文献类型：
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作者：
Xiaoman Li;Jiawei Huang;Liang Xu;Ping Liu;Yueting Wei
本文已经建立了烯烃、二硒醚和亚砜亚胺的四丁基三溴化铵介导的三组分反应，提供了直接和无金属地获得不同的β-芳基硒代亚砜亚胺衍生物。这种区域选择性亚砜亚胺基硒化方案在温和和环境条件下有效地进行，通常具有良好的产率。该合成策略具有步骤和原子经济性、实用性、底物范围广、可实现克级合成等特点。
A tetrabutylammonium tribromide-mediated three-component reaction of alkenes, diselenides, and sulfoximines has been established herein, providing direct and metal-free access to diverse β-arylseleno sulfoximine derivatives. This regioselective sulfoximido-selenization protocol proceeds efficiently under mild and ambient conditions with generally good yields. This strategy is featured by step and atom economy, practicability, a broad substrate scope, and gram-scale synthesis.