Selective cone photoreceptor injury in acute macular neuroretinopathy.
Selective cone photoreceptor injury in acute macular neuroretinopathy.
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DOI：
10.1097/iae.0b013e31828cd03a
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发表时间：
2013-09
期刊：
影响因子：
--
通讯作者：
Weinberg DV
中科院分区：
文献类型：
--
作者：
Hansen SO;Cooper RF;Dubra A;Carroll J;Weinberg DV
To evaluate retinal structural and functional abnormalities in a patient with Acute Macular Neuroretinopathy (AMN). An adaptive optics scanning light ophthalmoscope (AOSLO) was used to image the photoreceptor mosaic and assess rod and cone structure. Spectral domain optical coherence tomography (SD-OCT) was used to examine retinal lamination. Microperimetry was used to assess function across the macula. Microperimetry showed reduced function of localized areas within retinal lesions corresponding to subjective scotomas. SD-OCT imaging revealed attenuation of two outer retinal bands typically thought to reflect photoreceptor structure. AOSLO images of the photoreceptor mosaic revealed a heterogeneous presentation within these lesions. There were areas containing non-waveguiding cones and other areas of decreased cone density where the remaining rods had expanded to fill in the vacant space. Within these lesions, cone densities were shown to be significantly lower than eccentricity matched areas of normal retina, as well as accepted histological measurements. A 6-month follow up revealed no change in rod or cone structure. Imaging of AMN using an AOSLO shows a preferential disruption of cone photoreceptor structure within the region of decreased retinal sensitivity (as measured by microperimetry). AO-based imaging tools provide a noninvasive way to assess photoreceptor structure at a level of detail that is not resolved by use of conventional SD-OCT or other clinical measures.
