Increased levels of irisin in people with long-standing Type1 diabetes
Increased levels of irisin in people with long-standing Type1 diabetes
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DOI：
10.1111/dme.12731
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发表时间：
2015-09-01
影响因子：
3.5
通讯作者：
Carlsson, P. O.
中科院分区：
文献类型：
--
作者：
Espes, D.;Lau, J.;Carlsson, P. O.
背景鸢尾素刺激小鼠白色脂肪组织的布朗宁并改善代谢控制。最近描述的另一种激素β-萎缩素通过诱导细胞增殖来改善小鼠的代谢控制。在体外，鸢尾素刺激大鼠脂肪细胞中betatrophin的表达。人们对开发靶向或使用这些激素治疗肥胖和糖尿病的药物有很大的兴趣。我们以前曾报道过1型糖尿病患者的betatrophin水平升高，目的探讨1型糖尿病患者血清中鸢尾素水平的变化及其与betatrophin的相关性。方法采用酶联免疫吸附试验（ELISA）检测1型糖尿病患者血清中鸢尾素和betatrophin的水平。在45个人与1型糖尿病和25名健康controls.ResultsIrisin水平增加的人与1型糖尿病，尤其是在妇女。观察到鸢尾素水平与1型糖尿病发病年龄和血浆三酰甘油水平呈负相关。有趣的是，在患有1型糖尿病的女性中，还观察到Irisin和胰岛素剂量之间的负相关性。当计算所有研究参与者的相关性，观察到鸢尾素和总betatrophin之间的正相关性，但不是鸢尾素和全长betatrophin.ConclusionWe报告的人1型糖尿病，特别是女性的循环水平增加的鸢尾素。对于患有1型糖尿病的女性，Irisin的水平与较低的胰岛素需求相关。显然需要进一步的研究来确定Irisin在1型糖尿病中的作用。
BackgroundIrisin stimulates browning of white adipose tissue and improves metabolic control in mice. Betatrophin, another recently described hormone, improves metabolic control in mice by inducing -cell proliferation. Invitro, irisin stimulates the expression of betatrophin in rat adipocytes. There is a great interest in developing drugs that target or use these hormones for the treatment of obesity and diabetes. We have previously reported on increased levels of betatrophin in people with Type1 diabetes, but the levels of irisin are currently unknown.AimTo characterize the levels of irisin in Type1 diabetes and investigate a potential correlation with betatrophin.MethodsIrisin and betatrophin were measured by enzyme-linked immunosorbant assay (ELISA) in 45 individuals with Type1 diabetes and in 25 healthy controls.ResultsIrisin levels were increased in people with Type1 diabetes, and especially in women. Negative correlations between irisin levels and age at onset of Type1 diabetes and plasma triacylglycerol levels were observed. Interestingly, in women with Type1 diabetes a negative correlation between irisin and insulin doses was also observed. When computing correlations for all study participants, a positive correlation between irisin and total betatrophin was observed, but not between irisin and full-length betatrophin.ConclusionWe report on increased circulating levels of irisin in people with Type1 diabetes, especially in women. For women with Type1 diabetes, the levels of irisin correlated with lower insulin requirements. Further studies are clearly needed to determine the role of irisin in Type1 diabetes.