Serum hyaluronan levels and radiographic knee and hip osteoarthritis in African Americans and Caucasians in the Johnston County Osteoarthritis Project
Serum hyaluronan levels and radiographic knee and hip osteoarthritis in African Americans and Caucasians in the Johnston County Osteoarthritis Project
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DOI：
10.1002/art.20724
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发表时间：
2005-01-01
影响因子：
--
通讯作者：
Jordan, JM
中科院分区：
文献类型：
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作者：
Elliott, AL;Kraus, VB;Jordan, JM
目标。血清透明质酸(HA)已被认为是骨关节炎(OA)的潜在生物标志物。我们研究了不同种族、以人群为基础的样本中血清透明质酸与放射学骨性关节炎之间的关系。受试者选自约翰斯顿县骨性关节炎项目，采用分层简单随机抽样，根据膝关节骨关节炎的放射学状况、种族、性别和年龄组来达到平衡。采用酶联免疫吸附试验检测血清透明质酸。放射学上的骨关节炎变量包括膝关节骨关节炎、膝关节骨关节炎偏侧、膝关节骨关节炎严重程度、伴随的膝关节和髋关节骨关节炎，以及膝关节和髋关节骨关节炎受累的总数。采用协方差分析，调整种族、性别、年龄、体重指数(BMI)和自我报告的合并症，评估不同组间自然对数转换HA(血清HA)平均水平的差异。血清透明质酸水平与所有放射性骨性关节炎的定义均呈正相关(P<；0.0001)。高加索人血清HA水平较高(P=0.0094)，男性较高(P=0.0038)，且与年龄呈中度正相关(r=0.35P&t；0.0001)。调整后，与放射学上的骨性关节炎、种族、性别和年龄的相关性仍然具有统计学意义(P<；0.0045)。种族与其他协变量之间不存在交互作用。这些横断面数据支持血清HA作为放射性骨性关节炎的生物标志物的作用。不同种族、性别和年龄的血清HA水平的变化不能用放射学上的骨关节炎、体重指数或合并症来解释。血清HA和合并症之间缺乏强烈的混杂，这进一步支持了血清HA作为潜在的生物标志物的作用。
Objective. Serum hyaluronan (HA) has been proposed as a potential biomarker of osteoarthritis (OA). We examined associations between serum HA and radiographic OA in an ethnically diverse, population-based sample.Methods. Participants were selected from the Johnston County Osteoarthritis Project, using stratified simple random sampling to achieve balance according to radiographic knee OA status, ethnic group, sex, and age group. Serum HA was measured by enzyme-linked immunosorbent assay. Radiographic OA variables included knee OA, knee OA laterality, knee OA severity, concomitant knee and hip OA, and total number of OA-affected knee and hip joints. Analysis of covariance was used to assess differences in mean serum levels of natural log-transformed HA (In serum HA) between groups, adjusting for ethnicity, sex, age, body mass index (BMI), and self-reported comorbidities.Results. Levels of In serum HA were positively associated with all definitions of radiographic OA (P < 0.0001). Levels of In serum HA were higher in Caucasians (P = 0.0094) and in men (P = 0.0038) and were moderately correlated with age (r = 0.35, P < 0.0001). The associations with radiographic OA, ethnicity, sex, and age remained statistically significant after adjustment (P < 0.0045). There were no interactions between ethnicity and the other covariates.Conclusion. These cross-sectional data support a role for serum HA as a biomarker of radiographic OA. The variations in levels of serum HA attributable to ethnicity, sex, and age were not explained by radiographic OA, BMI, or comorbidities. The lack of strong confounding between serum HA and comorbidities further supports a role for serum HA as a potential biomarker.