Vasa vasorum formation is associated with rupture of intracranial aneurysms
Vasa vasorum formation is associated with rupture of intracranial aneurysms
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DOI：
10.3171/2019.5.jns19405
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发表时间：
2020-09-01
影响因子：
4.1
通讯作者：
Aoki, Tomohiro
中科院分区：
文献类型：
--
作者：
Miyata, Haruka;Imai, Hirohiko;Aoki, Tomohiro
目的：尽管现代医疗水平不断提高，蛛网膜下腔出血（SAH）的预后仍很差。因此，必须开发一种新的治疗策略来预防颅内动脉瘤（IA）破裂或开发一种新的诊断标记物来预测易破裂病变。因此，在本研究中，作者建立了一种大鼠模型，其中IA自发破裂，并检查此模型，以澄清与病变破裂相关的组织病理学特征。方法雌性Sprague道利大鼠进行双侧卵巢切除术，结扎左颈总动脉，右颈外动脉，右翼腭动脉，诱导全身性高血压，结果动脉瘤性SAH发生在三分之一的操作动物和破裂的IA的位置是专门在后交通动脉或前交通动脉（PCoA/ACoA）。使用破裂的IA、在PCoA或ACoA处诱导的易破裂的IA以及在从未破裂的大脑前动脉-嗅动脉分叉处诱导的IA进行的组织学检查揭示了血管形成是与IA破裂相关的事件。结论作者提出了外膜结构变化的贡献，即，血管的形成，到动脉瘤的破裂。这项研究的结果提供了关于IA发病机制的重要见解。
OBJECTIVE Subarachnoid hemorrhage (SAH) has a poor outcome despite modern advancements in medical care. The development of a novel therapeutic strategy to prevent rupture of intracranial aneurysms (IAs) or a novel diagnostic marker to predict rupture-prone lesions is thus mandatory. Therefore, in the present study, the authors established a rat model in which IAs spontaneously rupture and examined this model to clarify histopathological features associated with rupture of lesions.METHODS Female Sprague Dawley rats were subjected to bilateral ovariectomy; the ligation of the left common carotid, the right external carotid, and the right pterygopalatine arteries; induced systemic hypertension; and the administration of a lysyl oxidase inhibitor.RESULTS Aneurysmal SAH occurred in one-third of manipulated animals and the locations of ruptured IAs were exclusively at a posterior or anterior communicating artery (PCoA/ACoA). Histopathological examination using ruptured IAs, rupture-prone IAs induced at a PCoA or ACoA, and IAs induced at an anterior cerebral artery-olfactory artery bifurcation that never ruptured revealed the formation of vasa vasorum as an event associated with rupture of IAs.CONCLUSIONS The authors propose the contribution of a structural change in an adventitia, i.e., vasa vasorum formation, to the rupture of IAs. Findings from this study provide important insights about the pathogenesis of IAs.