REDUCING PULSE PRESSURE IN HYPERTENSION MAY NORMALIZE SMALL ARTERY STRUCTURE
REDUCING PULSE PRESSURE IN HYPERTENSION MAY NORMALIZE SMALL ARTERY STRUCTURE
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DOI：
10.1161/01.hyp.18.6.722
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发表时间：
1991-12-01
期刊：
影响因子：
8.3
通讯作者：
CHRISTENSEN, KL
中科院分区：
文献类型：
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作者：
CHRISTENSEN, KL
为了研究小动脉结构与不同血压参数之间的关系，对4 - 24周龄（共20周）的自发性高血压大鼠进行了5种不同的抗高血压治疗：两种血管紧张素转换酶抑制剂（培哚普利和卡托普利），钙拮抗剂（伊拉地平），β受体阻滞剂（美托洛尔）和血管扩张剂（肼苯哒嗪）。在24周龄时，测量24小时血压，并从每只动物中取出两条肠系膜阻力血管。未经治疗的高血压大鼠和血压正常的对照大鼠的血压分别为227/135 mm Hg（收缩压/舒张压）和161/106 mm Hg。两种品系的心率分别为376 min-1和295 min-1。除美托洛尔不能降低脉压外，所有治疗均降低了所有血压参数。在小动脉中，中膜横截面积不受处理影响。当一个简单的相关性分析，脉压被发现更密切相关（r = 0.64，p < 0.001）与所研究的任何其他压力参数相比：收缩压（r = 0.51，p = 0.011）、平均值（r = 0.41，p = 0.05）或舒张压（r = 0.28，p = 0.19）。当进行协方差分析时，包括脉压、平均血压和心率，它们也与中膜/管腔比显著相关，81%的中膜/管腔比的变化可以由三个协变量的变化解释（p < 10（-5）），脉压是主要因素。总之，它表明，在降压治疗过程中降低脉压和心率可能是重要的，在防止发展异常的小动脉结构在高血压。
To investigate the relation between the small artery structure and different blood pressure parameters, spontaneously hypertensive rats were treated from 4 to 24 weeks of age (20 weeks in total) with five different antihypertensive therapies: two angiotensin converting enzyme inhibitors (perindopril and captopril), a calcium antagonist (isradipine), a beta-blocker (metoprolol), and a vasodilator (hydralazine). At 24 weeks of age, 24-hour blood pressure was measured, and two mesenteric resistance vessels were taken from each animal. Blood pressure was 227/135 mm Hg (systolic/diastolic) and 161/106 mm Hg in untreated hypertensive and normotensive control rats, respectively. Heart rates were 376 min-1 and 295 min-1 for the two strains. All treatments reduced all blood pressure parameters except for metoprolol, which did not reduce pulse pressure. In the small arteries, the media cross-sectional area was unaffected by the treatments. When a simple correlation analysis was made, pulse pressure was found to correlate more closely (r = 0.64, p < 0.001) to the resistance vessel media/lumen ratio than any of the other pressure parameters studied: systolic (r = 0.51, p = 0.011), mean (r = 0.41, p = 0.05), or diastolic (r = 0.28, p = 0.19). When an analysis of covariance was performed that included pulse pressure, mean blood pressure, and heart rate, which also correlated significantly to the media/lumen ratio, 81% of the variation in the media/lumen ratio could be accounted for by the variation in the three covariates (p < 10(-5)), pulse pressure being the major factor. In conclusion, it is indicated that a reduction in pulse pressure and heart rate during antihypertensive treatment may be important in preventing the development of abnormal small artery structure in hypertension.