RENAL EXCRETION OF PROTEINS AND ENZYMES IN WORKERS EXPOSED TO CADMIUM
RENAL EXCRETION OF PROTEINS AND ENZYMES IN WORKERS EXPOSED TO CADMIUM
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DOI：
10.1111/j.1365-2362.1979.tb01662.x
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发表时间：
1979-01-01
影响因子：
5.5
通讯作者：
LAUWERYS, R
中科院分区：
文献类型：
--
作者：
BERNARD, A;BUCHET, JP;LAUWERYS, R
蛋白尿率和。β的相对清除率。测定了42名接触Cd的工人和77名对照工人的2-微球蛋白、类造血球蛋白、白蛋白、转铁蛋白和免疫球蛋白G。一种管状型蛋白尿，伴有β -的排泄增加。2-微球蛋白和肾小球型蛋白尿，常伴有orosomucoid、白蛋白、转铁蛋白和IgG的排泄增加，主要见于接触Cd超过25年且血中Cd浓度超过1 μ m的工人。g Cd/100 ml，尿中Cd/10 .mu。g Cd/g肌酐。血浆β水平升高也提示肾小球功能障碍。2-微球蛋白和肌酐。肾小管和肾小球损伤发生率相同，并不一定相关。.beta的增加版本。-半乳糖苷酶的变化提示Cd可损伤部分上皮细胞。
The proteinuria rate and the relative clearances of .beta.2-microglobulin, orosomucoid, albumin, transferrin and Ig[immunoglobin]G were measured in 42 workers exposed to Cd and in 77 control workers. A tubular type proteinuria with an increased excretion of .beta.2-microglobulin and often also a glomerular type proteinuria with an increased excretion of orosomucoid, albumin, transferrin and IgG were observed mainly in workers exposed to Cd for more than 25 yr and whose Cd concentration in blood exceeded 1 .mu.g Cd/100 ml and that in urine 10 .mu.g Cd/g creatinine. The glomerular dysfunction was also suggested by an increased plasma level of .beta.2-microglobulin and creatinine. Tubular and glomerular inpairments occurred with the same prevalence and were not necessarily associated. The increased release of .beta.-galactosidase by the kidney suggested that Cd can damage some epithelial cells.