The Emerging Field of Nutritional Mental Health: Inflammation, the Microbiome, Oxidative Stress, and Mitochondrial Function
The Emerging Field of Nutritional Mental Health: Inflammation, the Microbiome, Oxidative Stress, and Mitochondrial Function
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DOI：
10.1177/2167702614555413
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发表时间：
2015-11-01
影响因子：
4.8
通讯作者：
McLeod, Kevin
中科院分区：
文献类型：
--
作者：
Kaplan, Bonnie J.;Rucklidge, Julia J.;McLeod, Kevin
我们生活在一个理解精神障碍病因的变革时刻。上一次理解的飞跃发生在60年前，这导致我们将精神药理学纳入我们的课程，以解决神经递质功能的化学基础，特别是通过当时流行的儿茶酚胺假说解释。当前的革命范围更广，包括炎症、微生物组失衡（肠道生态失调）、氧化应激和线粒体输出受损如何影响大脑功能的快速积累的知识。对抗炎症、恢复正常肠道功能、减少氧化应激和改善线粒体代谢的适当干预措施包括生活方式变量，包括营养素和益生菌。这篇文章邀请读者跟上这种新兴的精神疾病的生物学基础模型，因为它对那些有兴趣减轻精神障碍患者痛苦的读者特别重要。本概述介绍了一个新的领域在精神卫生的基础：营养精神病学/心理学。
We live in a transformational moment for understanding the etiology of mental disorders. The previous leap in understanding occurred 60 years ago, which led us to incorporate psychopharmacology into our curricula to address the chemical basis of neurotransmitter function, especially as explained through the then-popular catecholamine hypothesis. The current revolution is broader, consisting of the rapidly accumulating knowledge of how inflammation, microbiome imbalance (gut dysbiosis), oxidative stress, and impaired mitochondrial output affect brain function. Suitable interventions for fighting inflammation, restoring normal gut function, reducing oxidative stress, and improving mitochondrial metabolism incorporate lifestyle variables, including nutrients and probiotics. This article invites readers to stay abreast of this emerging model of the biological basis of mental illness, given that it has particular relevance for those readers interested in alleviating the suffering of individuals with mental disorders. This overview describes the basis for a new field in mental health: nutritional psychiatry/ psychology.