Structure-based design of immunologically active therapeutic peptides
Structure-based design of immunologically active therapeutic peptides
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DOI：
10.1007/bf02786441
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发表时间：
1998-01-01
影响因子：
4.4
通讯作者：
Greene, MI
中科院分区：
文献类型：
--
作者：
Murali, R;Greene, MI
肽是柔性分子，可以采用蛋白质的局部结构特征，如二级结构、疏水性、静电荷分布等，并模仿其功能。与免疫学相关的治疗性肽模拟物是通过改造蛋白质和受体的表面环结构而开发的。靶向分子类别包括含有免疫球蛋白折叠的分子：抗体、细胞表面 CD4 受体和含有胱氨酸结的受体家族成员：肿瘤坏死因子 (TNF)、CD40 和 p185/Neu 受体。我们使用分子识别中涉及的环作为模板，并开发了干扰目标分子功能的肽模拟物。在本文中，讨论了两个分子靶标：(1) 包含免疫球蛋白折叠的 CD4 受体和 (2) 包含胱氨酸结的 TNF 受体 (TNFR)。
Peptides are flexible molecules and can adopt local structural features of protein, such as secondary structure, hydrophobicity, and distribution of electrostatic charges, and so forth, and mimic their functions. Therapeutic peptidomimetics that are immunologically relevant are developed by engineering the surface loop structures in the proteins and receptors. The class of molecules targeted include immunoglobulin fold-containing molecules: antibody, cell-surface CD4 receptors and cystine-knot-containing receptor family members: tumor necrosis factor (TNF), CD40, and p185/Neu receptors. We have used the loops involved in the molecular recognition as a template and developed peptidomimetics that interfere with the functions of the target molecules. In this article, two molecular targets are discussed: (1) immunoglobulin fold-containing CD4 receptor and (2) cystine-knot-containing TNF receptor (TNFR).